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Perioperative Care of Patients with Inflammatory Bowel Disease: Focus on Nutritional Support

机译:炎性肠病患者的围手术期护理:注重营养支持

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摘要

Patients with inflammatory bowel disease (IBD) commonly require surgery despite the availability of an increasingly large repertoire of powerful immunosuppressive medications for the treatment of IBD. Optimizing patients' care preoperatively is crucial to obtaining good surgical outcomes. This review discusses preoperative assessment and management principles including assessing disease location and activity with cross-sectional or endoscopic imaging, addressing modifiable risk factors (i.e., stopping smoking, weaning steroids, and correcting anemia), and properly managing medications. The major focus of our literature review is the evaluation for malnutrition, a common finding that affects up to 70% of patients with IBD and a well-known, independent risk factor for adverse postoperative outcomes. Our review confirms that whenever feasible, oral or enteral nutrition (EN) is the preferred method of nutritional support; parenteral nutrition (PN) should be reserved for nutritionally deficient IBD patients unable to tolerate EN. In selected patients, recent data demonstrated that the use of preoperative PN resulted in improved nutritional status, fewer postoperative complications, and reduced disease severity. Our review highlights the need for well-designed, prospective trials investigating perioperative nutritional support in patients with IBD. Future studies should perform modern nutritional assessment, standardize for diet, and include patients with UC since this subset of patients is underrepresented in existing studies. In addition, relevant outcome of interest specific to Crohn's disease (CD) patients such as length of small bowel resected, number of anastomoses, and need for an ostomy should be included as these patients may require repeated small bowel resections.
机译:尽管有越来越多的用于治疗IBD的强力免疫抑制药物,但炎症性肠病(IBD)患者通常仍需要手术。术前优化患者的护理对于获得良好的手术效果至关重要。这篇综述讨论了术前评估和管理原则,包括通过横断面或内窥镜成像评估疾病的位置和活动,解决可改变的危险因素(即戒烟,戒断类固醇和纠正贫血)以及正确管理药物。我们文献综述的主要重点是营养不良的评估,营养不良的普遍发现影响多达70%的IBD患者,并且是众所周知的术后不良预后的独立危险因素。我们的评论证实,只要可行,口服或肠内营养(EN)是首选的营养支持方法;对于不能耐受EN的营养缺乏的IBD​​患者,应保留肠外营养(PN)。在选定的患者中,最新数据表明,术前PN的使用可改善营养状况,减少术后并发症并降低疾病严重性。我们的评论强调需要进行精心设计的前瞻性试验,以研究IBD患者围手术期的营养支持。未来的研究应进行现代营养评估,使饮食标准化,并包括患有UC的患者,因为这部分患者在现有研究中代表性不足。此外,应包括特定于克罗恩病(CD)患者的相关关注结局,例如切除小肠的长度,吻合口的数量以及是否需要造口术,因为这些患者可能需要反复进行小肠切除术。

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