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A Review of Computational Methods for Finding Non-Coding RNA Genes

机译:寻找非编码RNA基因的计算方法的综述。

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摘要

Finding non-coding RNA (ncRNA) genes has emerged over the past few years as a cutting-edge trend in bioinformatics. There are numerous computational intelligence (CI) challenges in the annotation and interpretation of ncRNAs because it requires a domain-related expert knowledge in CI techniques. Moreover, there are many classes predicted yet not experimentally verified by researchers. Recently, researchers have applied many CI methods to predict the classes of ncRNAs. However, the diverse CI approaches lack a definitive classification framework to take advantage of past studies. A few review papers have attempted to summarize CI approaches, but focused on the particular methodological viewpoints. Accordingly, in this article, we summarize in greater detail than previously available, the CI techniques for finding ncRNAs genes. We differentiate from the existing bodies of research and discuss concisely the technical merits of various techniques. Lastly, we review the limitations of ncRNA gene-finding CI methods with a point-of-view towards the development of new computational tools.
机译:在过去的几年中,发现非编码RNA(ncRNA)基因已成为生物信息学的最新趋势。 ncRNA的注释和解释面临许多计算智能(CI)挑战,因为它需要CI技术领域相关的专家知识。此外,有许多预测的类别尚未得到研究人员的实验验证。最近,研究人员应用了许多CI方法来预测ncRNA的类别。但是,多样化的CI方法缺乏明确的分类框架来利用过去的研究。一些综述文章试图总结CI的方法,但集中在特定的方法论观点上。因此,在本文中,我们比以前可用的CI技术更详细地总结了用于发现ncRNAs基因的CI技术。我们区别于现有的研究机构,并简要讨论各种技术的技术优点。最后,我们以开发新计算工具的观点回顾了ncRNA基因发现CI方法的局限性。

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