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The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells

机译：染色质修饰剂对小鼠胚胎干细胞中基因座复制时间的影响

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BackgroundThe time of locus replication during S-phase is tightly regulated and correlates with chromatin state. Embryonic stem (ES) cells have an unusual chromatin profile where many developmental regulator genes that are not yet expressed are marked by both active and repressive histone modifications. This poised or bivalent state is also characterized by locus replication in early S-phase in ES cells, while replication timing is delayed in cells with restricted developmental options.

机译：背景S期的基因座复制时间受到严格调节，并与染色质状态相关。胚胎干（ES）细胞具有不同寻常的染色质特征，其中许多尚未表达的发育调节基因均以活性和抑制性组蛋白修饰为标志。这种平衡或二价状态的特征还在于ES细胞在早期S期复制，而在发育选择受限的细胞中复制时机被延迟。

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期刊名称 Genome Biology
作者
Helle F Jørgensen; Véronique Azuara; Shannon Amoils; Mikhail Spivakov; Anna Terry; Tatyana Nesterova; Bradley S Cobb; Bernard Ramsahoye; Matthias Merkenschlager; Amanda G Fisher;
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年(卷),期 2007(8),8
年度 2007
页码 R169
总页数 13
原文格式 PDF
正文语种
中图分类生物学;
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1. Nodal mutant eXtraembryonic ENdoderm (XEN) stem cells upregulate markers for the anterior visceral endoderm and impact the timing of cardiac differentiation in mouse embryoid bodies Nodal mutant eXtraembryonic ENdoderm (XEN) stem cells upregulate markers for the anterior visceral endoderm and impact the timing of cardiac differentiation in mouse embryoid bodies Nodal mutant eXtraembryonic ENdoderm (XEN) stem cells upregulate markers for the anterior visceral endoderm and impact the timing of cardiac differentiation in mouse embryoid bodies [J] . Ann C. Foley, Wenrui Liu, Kemar Brown, Biology Open . 2012,第3期

机译：淋巴结突变性胚胎内胚层（XEN）干细胞上调内脏内胚层的标志物并影响小鼠胚状体中心脏分化的时机淋巴结突变性胚胎内膜胚层（XEN）干细胞上调内脏内胚层的标志物并影响心脏分化的时间小鼠胚状体中的节点突变型胚胎内胚层（XEN）干细胞上调内脏内胚层的标志物并影响小鼠胚状体中心脏分化的时机
2. MRAS GTPase is a novel stemness marker that impacts mouse embryonic stem cell plasticity and Xenopus embryonic cell fate [J] . MathieuM.-E., FaucheuxC., SaucourtC., Development . 2013,第16期

机译：MRAS GTPase是一种新型干标记，可影响小鼠胚胎干细胞的可塑性和非洲爪蟾胚胎细胞的命运
3. {MAD2L2} Promotes Open Chromatin in Embryonic Stem Cells and?Derepresses the Dppa3 Locus [J] . Ali Rahjouei, Mehdi Pirouz, Michela Di Virgilio, Stem Cell Reports . 2017,第4期

机译：{MAD2L2}促进胚胎干细胞中的染色质开放并抑制Dppa3基因座。
4. Selective isolation of chromatin-associated proteins reveals dynamics of chromatin composition in mouse embryonic stem cells [C] . Mahmoud-Reza Rafiee, Jeroen Krijgsveld ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：染色质相关蛋白的选择性分离揭示了小鼠胚胎干细胞中染色质组合物的动态
5. Proteomic and transcriptional analysis of components of the DNA replication and repair machinery in mouse embryonic stem cells. [D] . Sellami, Nadia. 2013

机译：小鼠胚胎干细胞中DNA复制和修复机制的组成部分的蛋白质组和转录分析。
6. Embryonic timing axial stem cells chromatin dynamics and the Hox clock [O] . Jacqueline Deschamps, Denis Duboule 2017

机译：胚胎时间轴向干细胞染色质动力学和Hox时钟
7. The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells [O] . Helle F Jørgensen, Véronique Azuara, Shannon Amoils, 2007

机译：染色质修饰剂对小鼠胚胎干细胞中基因座复制时间的影响

The impact of chromatin modifiers on the timing of locus replication in mouse embryonic stem cells

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