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Beautiful Piles of Bones: An Interview with 2017 Genetics Society of America Medal Recipient David M. Kingsley

机译：美丽的骨头：2017年美国遗传学会奖章获得者大卫·金斯利（David M.Kingsley）访谈

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The Genetics Society of America Medal is awarded to an individual for outstanding contributions to the field of genetics in the last 15 years. Recipients of the GSA Medal are recognized for elegant and highly meaningful contributions to modern genetics, exemplifying the ingenuity of GSA membership. The 2017 recipient is David M. Kingsley, whose work in mouse, sticklebacks, and humans has shifted paradigms about how vertebrates evolve. Kingsley first fell in love with genetics in graduate school, where he worked on receptor mediated endocytosis with Monty Krieger. In his postdoctoral training he was able to unite genetics with his first scientific love: vertebrate morphology. He joined the group of Neal Copeland and Nancy Jenkins, where he led efforts to map the classical mouse skeletal mutation short ear. Convinced that experimental genetics had a unique power to reveal the inner workings of evolution, Kingsley then established the stickleback fish as an extraordinarily productive model of quantitative trait evolution in wild species. He and his colleagues revealed many important insights, including the discoveries that major morphological differences can map to key loci with large effects, that regulatory changes in essential developmental control genes have produced advantageous new traits, and that nature has selected the same genes over and over again to drive the stickleback’s skeletal evolution. Recently, Kingsley’s group has been using these lessons to reveal more about how our own species evolved.This is an abridged version of the interview. The full interview is available on the Genes to Genomes blog, at .

机译：美国遗传学学会奖章授予在过去15年中对遗传学领域做出杰出贡献的个人。 GSA奖章的获得者因其对现代遗传学的优雅和高度有意义的贡献而受到认可，这体现了GSA成员的独创性。 2017年的获奖者是大卫·金斯利（David M.Kingsley），他在老鼠，棘背动物和人类中的工作改变了脊椎动物如何进化的范式。金斯利首先在研究生院爱上了遗传学，在那里他与蒙蒂·克里格（Monty Krieger）进行受体介导的内吞作用。在博士后培训中，他能够将遗传学与他的第一个科学爱好：脊椎动物形态学结合在一起。他加入了尼尔·科普兰（Neal Copeland）和南希·詹金斯（Nancy Jenkins）的小组，在那里他领导绘制经典的小鼠骨骼突变短耳图。坚信实验遗传学具有揭示进化内部机制的独特能力，金斯利随后将无背fish鱼确立为野生物种数量性状进化的非凡生产模型。他和他的同事揭示了许多重要的见解，包括以下发现：主要的形态学差异可以映射到具有重要作用的关键基因座；基本发育控制基因的调控变化产生了有利的新特性；大自然又一次选择了相同的基因。再次推动了棘背鸟的骨骼进化。最近，金斯利（Kingsley）的小组一直在利用这些课程来揭示有关我们自己物种如何进化的更多信息。这是采访的节略版。完整的采访可以在基因到基因组博客上找到。

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期刊名称 Genetics
作者
David M. Kingsley;
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年(卷),期 2017(207),4
年度 2017
页码 1221–1222
总页数 2
原文格式 PDF
正文语种
中图分类遗传学;
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入库时间 2022-08-17 12:09:52

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Beautiful Piles of Bones: An Interview with 2017 Genetics Society of America Medal Recipient David M. Kingsley

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