Lethal Effects of Low and Null Activity Alleles of 6-Phosphogluconate Dehydrogenase in DROSOPHILA MELANOGASTER

摘要

EMS-induced "null" and low activity alleles for 6-phosphogluconate dehydrogenase were characterized with respect to enzymatic activity, relative viability, fertility, and the effective lethal phase. It was determined that flies hemizygous and homozygous for the low activity allele, Pgd^-, possessed a depressed developmental rate, diminished viability, and loss of female fertility. Heterozygotes for Pgd^- and a deficiency for Pgd⁺ were lethal. The "null" activity allele demonstrated a lethal phenotype in both the hemizygous and homozygous condition. The effective lethal phase for the "null" allele occurs during late embryonic development (20–22 hr).