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>Correlation of pulse wave velocity with left ventricular mass in patients with hypertension once blood pressure has been normalized
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Correlation of pulse wave velocity with left ventricular mass in patients with hypertension once blood pressure has been normalized
Vascular stiffness has been proposed as a simple method to assess arterial loading conditions of the heart which induce left ventricular hypertrophy (LVH). There is some controversy as to whether the relationship of vascular stiffness to LVH is independent of blood pressure, and which measurement of arterial stiffness, augmentation index (AI) or pulse wave velocity (PWV) is best. Carotid pulse wave contor and pulse wave velocity of patients (n=20) with hypertension whose blood pressure (BP) was under control (<140/90 mmHg) with antihypertensive drug treatment medications, and without valvular heart disease, were measured. Left ventricular mass, calculated from 2D echocardiogram, was adjusted for body size using two different methods: body surface area and height. There was a significant (P<0.05) linear correlation between LV mass index and pulse wave velocity. This was not explained by BP level or lower LV mass in women, as there was no significant difference in PWV according to gender (1140.1+67.8 vs 1110.6+57.7 cm/s). In contrast to PWV, there was no significant correlation between LV mass and AI. In summary, these data suggest that aortic vascular stiffness is an indicator of LV mass even when blood pressure is controlled to less than 140/90 mmHg in hypertensive patients. The data further suggest that PWV is a better proxy or surrogate marker for LV mass than AI and the measurement of PWV may be useful as a rapid and less expensive assessment of the presence of LVH in this patient population.
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机译:已经提出了血管刚度作为评估引起左心室肥大(LVH)的心脏的动脉负荷状况的简单方法。关于血管硬度与LVH的关系是否与血压无关,以及哪种动脉硬度,增强指数(AI)或脉搏波速度(PWV)的最佳测量方法存在争议。测量了在使用降压药物治疗药物且无瓣膜性心脏病的情况下,其血压(BP)处于控制范围(<140/90 mmHg)的高血压患者(n = 20)的颈动脉脉搏扭曲和脉搏波速度。根据2D超声心动图计算得出的左心室质量,使用两种不同的方法调整了体型:体表面积和身高。左心室质量指数与脉搏波速度之间存在显着的线性相关(P <0.05)。女性的BP水平或较低的LV量不能解释这一点,因为PWV的性别差异无统计学意义(1140.1 + 67.8 vs 1110.6 + 57.7 cm / s)。与PWV相比,LV质量与AI之间无显着相关性。总之,这些数据表明,即使将高血压患者的血压控制在140/90 mmHg以下,主动脉血管僵硬度仍是LV质量的指标。数据进一步表明,PWV是LV质量的替代指标或替代指标,优于AI,PWV的测量结果可作为对该患者人群中LVH的快速,廉价评估。
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