We aimed to evaluate whether mean platelet volume (MPV) and platelet distribution width (PDW) are helpful to identify complete thrombus resolution (CTR) after acute deep venous thrombosis (DVT). Patients who had first-time episode of acute proximal DVT were included in this retrospective study. 100 patients with DVT were divided into two groups according to absence (group 1; n = 68) or presence (group 2; n = 32) of CTR on doppler ultrasonography at month 6. There were no significant difference in admission MPV and PDW levels between group 1 and group 2. MPV (p = 0.03) and PDW (p < 0.001) levels at month 6 were significantly higher in group 1 than in group 2. CTR showed a moderate negative correlation with PDW at month 6 (ρ = -0.47) and a weak negative correlation with MPV at month 6 (ρ = −0.26). Logistic regression analysis showed that PDW (OR, 2.2; p = 0.004) at month 6 was an independent risk factor for the presence of residual venous thrombosis in DVT patients. Receiver operating characteristics analysis revealed that a 8.4 % decrease in admission MPV at month 6 provided 62 % sensitivity and 62 % specificity (AUC: 0.64) and a 15.4 % decrease in admission PDW at month 6 provided 87 % sensitivity and 94 % specificity (AUC: 0.89) for prediction of CTR in DVT patients. Percent change in admission MPV and PDW levels at month 6 may be used to identify the patients with CTR after a first episode of acute proximal DVT.
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机译：我们旨在评估平均血小板体积（MPV）和血小板分布宽度（PDW）是否有助于确定急性深静脉血栓形成（DVT）后的完整血栓消退率（CTR）。这项首次回顾性研究包括首次发生急性近端DVT的患者。 100名DVT患者在第6个月时根据多普勒超声检查的CTR缺失情况（第1组; n = 68）或存在（第2组; n = 32）分为两组。入院MPV和PDW水平无显着差异在第1组和第2组之间，第1个月第6个月的MPV（p = 0.03）和PDW（p <0.001）水平明显高于第2组。在第6个月，CTR与PDW呈中等程度的负相关（ρ=- 0.47）和第6个月与MPV的负相关性较弱（ρ= −0.26）。 Logistic回归分析显示，第6个月的PDW（OR，2.2; p = 0.004）是DVT患者中残留静脉血栓形成的独立危险因素。接收器操作特征分析显示，第6个月入院MPV下降8.4％可提供62％的敏感性和62％的特异性（AUC：0.64），第6个月入院PDW减少15.4％可提供87％的敏感性和94％的特异性（AUC ：0.89）预测DVT患者的CTR。急性近端DVT首次发作后，第6个月入院MPV和PDW水平的百分比变化可用于识别CTR患者。
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