首页> 美国卫生研究院文献>The Indian Journal of Medical Research >Interleukin-1β (IL-1β) IL-4 gene polymorphisms in patients with systemic lupus erythematosus (SLE) their association with susceptibility to SLE
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Interleukin-1β (IL-1β) IL-4 gene polymorphisms in patients with systemic lupus erythematosus (SLE) their association with susceptibility to SLE

机译:系统性红斑狼疮(SLE)患者白细胞介素1β(IL-1β)和IL-4基因多态性及其与SLE易感性的关系

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摘要

Background & objectives:Interleukin-1 (IL-1) is one of the pro-inflammatory cytokines that plays a main role in the regulation of immune and inflammatory responses. Interleukin 4 (IL-4) as an anti-inflammatory cytokine regulates balance between Th1 and Th2 immune responses. This study was undertaken to investigate the IL-1β and IL-4 genes polymorphisms in patients with systemic lupus erythematosus (SLE) and also association between the polymorphisms and susceptibility to SLE.
机译:背景与目的:白介素-1(IL-1)是促炎细胞因子之一,在调节免疫和炎症反应中起主要作用。白细胞介素4(IL-4)作为抗炎细胞因子调节Th1和Th2免疫反应之间的平衡。本研究旨在研究系统性红斑狼疮(SLE)患者的IL-1β和IL-4基因多态性,以及该多态性与SLE易感性之间的关系。

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