Association between polymorphisms and haplotypes of the beta-2 adrenergic receptor gene and asthma in a Chinese Han population

摘要

Conflicting data have been reported on the association of variants of the beta-2 adrenergic receptor (ADRB2) gene with asthma etiology. To provide a scientific basis for the prevention and treatment of asthma, the relationship between single nucleotide polymorphisms and haplotypes of ADRB2 and asthma was examined in a Chinese Han population. Six loci (base positions -2387, -47, 46, 79, 491, and 523) of ADRB2 were examined in a group of individuals with asthma (n = 429) and a control group of individuals who do not have the disease (n = 483). Polymorphisms at the -47 locus [odds ratio (OR) = 0.789, 95% confidence interval (CI): 0.398~0.961, P < 0.05) and the 79 locus (OR = 0.788, 95% CI: 0.394~0.948, P < 0.05) and haplotype III (CCGGC; OR = 0.705, 95% CI: 0.412~0.973, P < 0.05) were correlated with asthma susceptibility and may affect the incidence of asthma in a Chinese Han population by conferring a protective effect. By examining several polymorphisms and haplotypes, this study yields a more comprehensive examination of the role of the ADRB2 gene in the pathogenesis of asthma.