POLYMORPHISMS AND HAPLOTYPES OF THE ALPHA 2C ADRENERGIC RECEPTOR GENE

摘要

Methods and compositions for diagnosing and treating diseases are provided. The methods involve the discovery of a correlation between an α2C-adrenergic receptor gene polymorphism, a combination of polymorphisms or a haplotype and the occurrence of diseases such as heart failure, cardiac arrhythmias, hypertension, behavioral and learning disorders, psychiatric diseases such as depression, obesity, and diabetes mellitus. The invention further pertains to the use of such molecules and methods in the diagnosis, prognosis, and treatment selection for diseases such as heart failure, cardiac arrhythmias, hypertension, behavioral and learning disorders, psychiatric diseases such as depression, obesity, and diabetes mellitus. The invention also pertains to a composition of matter comprising polymorphisms and haplotypes of the α2C-adrenergic receptor.