Multiplex-Polymerase Chain Reaction for DetectingMicrodeletions in The Azoospermia Factor Region ofY Chromosome in Iranian Couples with Non-ObstructiveInfertility and Recurrent Pregnancy Loss

摘要

BackgroundApproximately 15% of couples are infertile with the male factor explaining approximately 50% of the cases. One of the main genetic factors playing a role in male infertility is Y chromosomal microdeletions within the proximal long arm of the Y chromosome (Yq11), named the azoospermia factor (AZF) region. Recent studies have shown there is a potential connection between deletions of the AZF region and recurrent pregnancy loss (RPL). The aim of this study is to examine this association by characterizing AZF microdeletions in two infertile groups: in men with non-obstructive infertility and in men with wives displaying RPL.