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Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): a study protocol for a randomized controlled trial

机译：小儿脓胸（DTPA）中的胸膜内Dornase和组织纤溶酶原激活剂：一项随机对照试验的研究方案

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摘要

BackgroundA randomized controlled trial of adults with empyema recently demonstrated decreased length of stay in hospital in patients treated with intrapleurally administered dornase alfa and fibrinolytics compared to fibrinolytics alone. Whether this treatment strategy is safe and effective in children remains unknown.

机译：背景一项针对成人脓胸的随机对照试验最近表明，与单独使用纤溶酶相比，接受胸膜内给药的脱氧核糖核酸酶和纤溶酶治疗的患者住院时间缩短。这种治疗策略在儿童中是否安全有效仍然未知。

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期刊名称 Current Controlled Trials in Cardiovascular Medicine
作者
Michael H. Livingston; Sanjay Mahant; Felix Ratjen; Bairbre L. Connolly; Kevin Thorpe; Muhammad Mamdani; Ian Maclusky; Sophie Laberge; Lucy Giglia; J. Mark Walton; Connie L. Yang; Ashley Roberts; Anna C. Shawyer; Mary Brindle; Simon J. Parsons; Cristina A. Stoian; Eyal Cohen;
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作者单位

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年(卷),期 2017(18),-1
年度 2017
页码 293
总页数 11
原文格式 PDF
正文语种
中图分类心血管疾病 ;
关键词
Empyema Children Chest tubes Fibrinolytic agents Randomized controlled trial;

机译：脓胸;儿童;胸管;纤溶剂;随机对照试验;

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专利

1. Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): a study protocol for a randomized controlled trial [J] . Michael H. Livingston, Sanjay Mahant, Felix Ratjen, Trials . 2017 ,第1期

机译：小儿脓胸（DTPA）中的胸膜内Dornase和组织纤溶酶原激活剂：一项随机对照试验的研究方案
2. Effectiveness of Intrapleural Tissue Plasminogen Activator and Dornase Alfa vs Tissue Plasminogen Activator Alone in Children with Pleural Empyema A Randomized Clinical Trial [J] . Livingston Michael H., Mahant Sanjay, Connolly Bairbre, JAMA pediatrics . 2020 ,第4期

机译：胸腔内纤溶酶原激活剂和DORNASE ALFA对组织纤溶酶原单独服用胸腔脓肿性临床试验的儿童组织纤溶酶原素活化剂的有效性
3. Cost-effectiveness of intrapleural use of tissue plasminogen activator and DNase in pleural infection: evidence from the MIST2 randomised controlled trial [J] . Luengo-Fernandez Ramon, Penz Erika, Dobson Melissa, The European respiratory journal : . 2019 ,第2期

机译：组织纤溶酶原激活剂和DNase intranural使用的成本效益胸膜感染：来自Mist2随机对照试验的证据
4. Strengthening Behavior and Social Functioning Among Persons with Autism Spectrum Conditions Using Artificial Intelligence and Behavioral Activation: Protocol for the Well-Being and Health for Loved onEs with ASD (WHOLE) Psychosocial Pilot Randomized Controlled Trial [C] . Pierre Bowrin, Usman Iqbal Medical Informatics Europe Conference . 2020

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5. Feasibility Study of a Randomized Controlled Trial Protocol to Examine the Effectiveness of Auriculotherapy (AT) in Improving Sleep Condition and Glycaemic Control in Clients with Type 2 Diabetes. [D] . Kwan, Yee Mei. 2013

机译：一项随机对照试验方案的可行性研究，以检查耳穴疗法（AT）改善2型糖尿病患者睡眠状况和血糖控制的有效性。
6. Recombinant human TNK tissue-type plasminogen activator (rhTNK-tPA) versus alteplase (rt-PA) as fibrinolytic therapy for acute ST-segment elevation myocardial infarction (China TNK STEMI): protocol for a randomised controlled non-inferiority trial [O] . Hai-bo Wang, Ping Ji, Xing-Shan Zhao, 2017

机译：重组人TNK组织型纤溶酶原激活物（rhTNK-tPA）与阿替普酶（rt-PA）作为纤溶治疗急性ST段抬高型心肌梗死（中国TNK STEMI）：一项随机对照非劣效性试验的方案
7. Cost-effectiveness of intrapleural use of tissue plasminogen activator and DNase in pleural infection: evidence from the MIST2 randomised controlled trial [O] . Ramon Luengo-Fernandez, Erika Penz, Melissa Dobson, 2019

机译：组织纤溶酶原激活剂和DNA酶在胸腔感染中的成本效益：来自MIST2随机对照试验的证据

Intrapleural Dornase and Tissue Plasminogen Activator in pediatric empyema (DTPA): a study protocol for a randomized controlled trial

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