Time-differentiated target temperature management after out-of-hospital cardiac arrest: a multicentre randomised parallel-group assessor-blinded clinical trial (the TTH48 trial): study protocol for a randomised controlled trial

摘要

BackgroundThe application of therapeutic hypothermia (TH) for 12 to 24 hours following out-of-hospital cardiac arrest (OHCA) has been associated with decreased mortality and improved neurological function. However, the optimal duration of cooling is not known. We aimed to investigate whether targeted temperature management (TTM) at 33 ± 1 °C for 48 hours compared to 24 hours results in a better long-term neurological outcome.