首页> 美国卫生研究院文献>Current Controlled Trials in Cardiovascular Medicine >The effect on knee-joint load of instruction in analgesic use compared with neuromuscular exercise in patients with knee osteoarthritis: study protocol for a randomized single-blind controlled trial (the EXERPHARMA trial)
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The effect on knee-joint load of instruction in analgesic use compared with neuromuscular exercise in patients with knee osteoarthritis: study protocol for a randomized single-blind controlled trial (the EXERPHARMA trial)

机译:与膝关节骨关节炎患者的神经肌肉锻炼相比止痛药对膝关节教学负荷的影响:一项随机单盲对照试验(EXERPHARMA试验)的研究方案

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摘要

BackgroundKnee osteoarthritis (OA) is a mechanically driven disease, and it is suggested that medial tibiofemoral knee-joint load increases with pharmacologic pain relief, indicating that pharmacologic pain relief may be positively associated with disease progression. Treatment modalities that can both relieve pain and reduce knee-joint load would be preferable. The knee-joint load is influenced by functional alignment of the trunk, pelvis, and lower-limb segments with respect to the knee, as well as the ground-reaction force generated during movement. Neuromuscular exercise can influence knee load and decrease knee pain. It includes exercises to improve balance, muscle activation, functional alignment, and functional knee stability. The primary objective of this randomized controlled trial (RCT) is to investigate the efficacy of a NEuroMuscular EXercise (NEMEX) therapy program, compared with optimized analgesics and antiinflammatory drug use, on the measures of knee-joint load in people with mild to moderate medial tibiofemoral knee osteoarthritis.
机译:背景膝关节骨关节炎(OA)是一种机械驱动的疾病,建议随着药物性疼痛缓解,胫骨股骨内侧膝关节负荷增加,这表明药物性疼痛缓解可能与疾病进展呈正相关。既能减轻疼痛又能减轻膝关节负荷的治疗方式将是可取的。膝关节负荷受躯干,骨盆和下肢节段相对于膝盖的功能对齐以及运动过程中产生的地面反作用力的影响。神经肌肉运动可以影响膝盖负荷并减轻膝盖疼痛。它包括改善平衡,肌肉激活,功能对准和功能性膝盖稳定性的练习。这项随机对照试验(RCT)的主要目的是研究NEuroMuscularcular Exercise(NEMEX)治疗计划与优化的止痛药和抗炎药的使用相比,对中度至中度内侧患者的膝关节负重的作用胫股骨关节炎。

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