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  • 刊频： Quarterly
  • NLM标题： Chronic Dis Transl Med
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共206条结果
  • 1.

    【2hr】Integrated medical rehabilitation delivery in China

    包量

    机译 中国综合医疗康复服务
    摘要：Currently, China has a growing need for rehabilitative care; however, rehabilitative care has been underdeveloped for decades. Since the end of 2010, pilot programs in 46 cities (districts) of 14 provinces have been initiated by the Ministry of Health in China to establish formal arrangements for facilitating the delivery of continuous medical rehabilitative care for local communities. After 2 years of pilot work, an evaluation was conducted by researchers. This paper reviews the current status of rehabilitative care in China and discusses the findings of the nationwide pilot program on the integrated rehabilitative service. Some key mechanisms and main issues were identified after analyzing the preliminary outcomes of some of the pilot programs.
  • 2.

    【2hr】The growth of chronic conditions: Search for solutions to the problem

    包量

    机译 慢性病的增长：寻找问题的解决方案
    • 作者：Dmitry Mednis
    • 刊名：Chronic Diseases and Translational Medicine
    • 2017年第2期
    摘要：The chronic conditions growth is determined by an increase of cases of adaptive system imbalance following a recent disease. One of its most significant causes is decrease of crisis importance (a stage of disease) as a moderator of a qualitative changeover of an adaptive system. The contemporary treatment methods increase efficiency of pre-crises adaptive responses, but simultaneously they equalize the crisis to a level, which is insufficient for complete after-crisis alignment of body defenses. But the crisis is the very key to a solution to a chronic conditions problem. One of the ways of the problem solving is medical interventions, which cause sparing provocation crisis and a successive changeover of an adaptive system. Based on this it is worth reviewing critically, studying and developing the existing experience of bio-regulatory therapy, where the principle of sparing provocation is often used. The new term definitions, such as “medical intervention”, “health problems”, “crisis” are described in terms of biomedicine. The patients and physicians should be motivated to deal with chronic conditions correction and the aforesaid sets new tasks before a health care system.
  • 3.

    【2hr】Association between circulating oxidized low-density lipoprotein and atherosclerotic cardiovascular disease

    包量

    机译 循环氧化型低密度脂蛋白与动脉粥样硬化性心血管疾病的关系
    • 作者：Shen GaoJing Liu
    • 刊名：Chronic Diseases and Translational Medicine
    • 2017年第2期
    摘要：Atherosclerosis is a chronic, progressive disease which eventually leads to coronary heart disease (CHD), ischemic stroke and other atherosclerotic cardiovascular disease (ASCVD). Numerous studies have demonstrated an atherogenic role of oxidized low-density lipoprotein (ox-LDL) in the progression of ASCVD. This article briefly reviews the atherogenic mechanism of ox-LDL, the methods of measuring ox-LDL in the circulation, effect of medical therapy and life-style modification on ox-LDL level, and the association between circulating ox-LDL and atherosclerosis, including clinical ASCVD events and subclinical atherosclerosis, in observational studies.
  • 4.

    【2hr】Association between the rs1042522 polymorphism in TP53 and prostate cancer risk: An updated meta-analysis

    包量

    机译 TP53中的rs1042522多态性与前列腺癌风险之间的关联：最新的荟萃分析
    摘要：ObjectiveThe proposal of the present study was to investigate whether the TP53 rs1042522 polymorphism confers susceptibility to prostate cancer (PCa), by performing an updated meta-analysis.
  • 5.

    【2hr】Effect of type 2 diabetic serum on the behavior of Whartons jelly-derived mesenchymal stem cells in vitro

    包量

    机译 2型糖尿病血清对沃顿氏胶质间充质干细胞体外行为的影响
    摘要：ObjectiveWharton jelly-derived mesenchymal stem cells (WJMSCs) exhibit multilineage differentiation potential and can be used to treat multiple organs. However, diabetes affects the repair capability of MSCs. The aim of this study was to evaluate the effect of diabetic patient-derived serum on WJMSC behavior.
  • 6.

    【2hr】Burden of chronic illness and associated disabilities in Bangladesh: Evidence from the Household Income and Expenditure Survey

    包量

    机译 孟加拉国的慢性病和相关残疾的负担：来自家庭收支调查的证据
    摘要：ObjectiveThe purpose of this study was to investigate the distribution of chronic illness and associated disability, out-of-pocket payment (OOPP), and other related factors using survey data from Bangladesh.
  • 7.

    【2hr】Paradoxical embolism: Experiences from a single center

    包量

    机译 矛盾的栓塞：来自一个中心的经验
    摘要：ObjectiveTo present our treatment experiences and the follow-up data of patients with paradoxical embolism (PDE).
  • 8.

    【2hr】Stroke screening and health-related physical fitness testing in medical staff members in Urumqi China

    包量

    机译 中国乌鲁木齐市医务人员中风筛查和健康相关的体能测试
    摘要：ObjectiveStroke is the leading cause of death and disability, and is closely related to a lack of exercise. Currently, most Chinese medical staff members lack exercise and may be at risk for stroke. We sought to determine the risk factors for stroke and study the significance of health-related physical fitness testing in stroke prevention among Chinese medical staff members.
  • 9.

    【2hr】Advancements in next-generation sequencing for diagnosis and treatment of non-small-cell lung cancer

    包量

    机译 非小细胞肺癌诊治的新一代测序技术的进展
    摘要：
  • 10.

    【2hr】Quantitative magnetic resonance imaging biomarkers in oncological clinical trials: Current techniques and standardization challenges

    包量

    机译 肿瘤临床试验中的定量磁共振成像生物标记物：当前技术和标准化挑战
    • 作者：Jie DengYi Wang
    • 刊名：Chronic Diseases and Translational Medicine
    • 2017年第1期
    摘要：Radiological imaging plays an important role in oncological trials to provide imaging biomarkers for disease staging, stratifying patients, defining dose setting, and evaluating the safety and efficacy of new candidate drugs and innovative treatment. This paper reviews the techniques of most commonly used quantitative magnetic resonance imaging (qMRI) biomarkers (dynamic contrast enhanced, dynamic susceptibility contrast, and diffusion weighted imaging) and their applications in oncological trials. Challenges of incorporating qMRI biomarkers in oncological trials are discussed including understanding biological mechanisms revealed by MRI biomarkers, consideration of rigorous trial design and standardized implementation of qMRI protocols.
  • 11.

    【2hr】Management of breast cancer brain metastases: Focus on human epidermal growth factor receptor 2-positive breast cancer

    包量

    机译 乳腺癌脑转移的管理：专注于人类表皮生长因子受体2阳性乳腺癌
    摘要：After the introduction of trastuzumab, a monoclonal antibody that binds to human epidermal growth factor receptor 2 (HER2), the overall survival (OS) among patients with HER2-positive breast cancer has been substantially improved. However, among these patients, the incidence of brain metastases (BM) has been increasing and an increased proportion of them have died of intracranial progression, which makes HER2-positive breast cancer brain metastases (BCBM) a critical issue of concern. For local control of limited BM, stereotactic radiosurgery (SRS) and surgical resection are available modalities with different clinical indications. Postoperative or preoperative radiation is usually delivered in conjunction with surgical resection to boost local control. Adjuvant whole-brain radiotherapy (WBRT) should be deferred for limited BM because of its impairment of neurocognitive function while having no benefit for OS. Although WBRT is still the standard treatment for local control of diffuse BM, SRS is a promising treatment for diffuse BM as the technique continues to improve. Although large molecules have difficulty crossing the blood brain barrier, trastuzumab-containing regimens are critical for treating HER2-positive BCBM patients because they significantly prolong OS. Tyrosine kinase inhibitors are more capable of crossing into the brain and they have been shown to be beneficial for treating BM in HER2-positive patients, especially lapatinib combined with capecitabine. The antiangiogenic agent, bevacizumab, can be applied in the HER2-positive BCBM scenario as well. In this review, we also discuss several strategies for delivering drugs into the central nervous system and several microRNAs that have the potential to become biomarkers of BCBM.
  • 12.

    【2hr】Revision of the concept of anti-angiogenesis and its applications in tumor treatment

    包量

    机译 修订抗血管生成的概念及其在肿瘤治疗中的应用
    摘要：Anti-angiogenesis therapy, by blocking formation of new blood vessels in tumors, is the standard-of-care therapy for various cancer types. The classic concept of anti-angiogenesis is expected to turn a tumor into a “dormant” disease. However, the combination of anti-angiogenesis agents with conventional therapeutics has generally produced only modest survival benefits for cancer patients in clinical trials. Therefore, the concept and applications of anti-angiogenesis have evolved dramatically along with lessons learned from recent clinical experience. In this article, we will discuss the revised concept of anti-angiogenesis therapy and the applications of anti-angiogenesis drugs, and focus particularly on how to utilize current anti-angiogenesis agents and develop new approaches to provide more benefits to patients with cancer.
  • 13.

    【2hr】Can axillary radiotherapy replace axillary dissection for patients with positive sentinel nodes? A systematic review and meta-analysis

    包量

    机译 前哨淋巴结阳性的患者可以用腋窝放疗代替腋窝清扫术吗？系统评价和荟萃分析
    摘要：ObjectiveTo compare the efficacy of axillary radiotherapy (ART) with that of completion axillary lymph node dissection (cALND) in clinically node-negative breast cancer patients with a positive sentinel lymph node.
  • 14.

    【2hr】Comparison of 627 patients with right- and left-sided colon cancer in China: Differences in clinicopathology recurrence and survival

    包量

    机译 中国627例左右结肠癌患者的比较：临床病理复发和生存率的差异
    摘要：ObjectiveRecent studies have reported increased mortality for right-sided colon cancers; however, the results are conflicting for different stage tumors. We examined the differences in clinicopathology between right- and left-sided colon cancers and the relationships between colon cancer location (right- and left-side) and 5-year disease-free survival (DFS) and overall survival (OS).
  • 15.

    【2hr】Diagnosis prevention and management of gestational diabetes mellitus

    包量

    机译 妊娠糖尿病的诊断预防和管理
    摘要：
  • 16.

    【2hr】The importance and strategy of diabetes prevention

    包量

    机译 糖尿病预防的重要性和策略
    • 作者：Bing-Yin Shi
    • 刊名：Chronic Diseases and Translational Medicine
    • 2016年第4期
    摘要：Diabetes has become one of the largest public health problems to date. Decreased physical activity, overnutrition, and nutrition transitions caused by changes in lifestyle contribute to the increasing incidence of chronic metabolic diseases as well as deaths related to them. The shift from undernutrition to overnutrition indicates that chronic diseases of affluence have become a public health problem; hence, sustainable health-related goals have been developed for the prevention of these diseases. Environmental factors and the gut microbiota influence metabolism in the human body. Several studies have proven that lifestyle interventions can effectively deter the progression of diabetes in individuals with impaired glucose tolerance. If the window of prevention is shifted earlier, diabetes may become a fortuitous event. Effective prevention needs high attention from the government and the participation of all citizens. Concrete scientific and reasonable measures also need to be developed by experts and scholars.
  • 17.

    【2hr】Exercise and its role in gestational diabetes mellitus

    包量

    机译 运动及其在妊娠糖尿病中的作用
    摘要：Gestational diabetes mellitus (GDM) refers to diabetes diagnosed in the second or third trimester of pregnancy that is not clearly either type 1 or type 2 diabetes. GDM is a common medical complication in pregnancy that has been rapidly increasing worldwide. GDM is associated with both short- and long-term health issues for both mothers and offspring. Consistent with type 2 diabetes, peripheral insulin resistance contributes to the hyperglycemia associated with GDM. Accordingly, it is important to identify strategies to reduce the insulin resistance associated with GDM. To date, observational studies have shown that exercise can be a non-invasive therapeutic option for preventing and managing GDM that can be readily applied to the antenatal population. However, the relevant mechanisms for these outcomes are yet to be fully elucidated. The present review aimed to explain the potential mechanisms of exercise from the perspective of reducing the insulin resistance, which is the root cause of GDM. Exercise recommendations and opinions of exercise during pregnancy are briefly summarized.
  • 18.

    【2hr】KRAS-related noncoding RNAs in pancreatic ductal adenocarcinoma

    包量

    机译 胰腺导管腺癌中与KRAS相关的非编码RNA
    摘要：Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a poor overall prognosis. However, curative resection during the early stages of the disease can greatly improve survival rates, highlighting the importance of early screening and detection. Studies of noncoding RNAs, primarily microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), provide important insights into strategies for the early detection of KRAS-driven PDAC. Here, we summarize our studies and review current reports on research investigating KRAS-related miRNAs and lncRNAs, emphasizing their aberrant expression, mechanisms, carcinogenic effects, and prognostic and predictive capacities in PDAC.
  • 19.

    【2hr】Circulating free DNA in the era of precision oncology: Pre- and post-analytical concerns

    包量

    机译 精密肿瘤学时代的游离DNA循环：分析前后的关注点
    摘要：Cancer treatment has entered the era of precision medicine, where knowledge of a patient's genetic profile is used to facilitate early diagnosis, drug selection, prognosis, prediction of drug responsiveness, the onset of secondary resistance, and relapse. Circulating free DNA (cfDNA) has emerged as an ideal source of genetic information for cancer patients, and numerous studies have explored its validity in various clinical applications. However, clinical implementation of cfDNA-based tests has been slow. In this review, we addressed some of the pre- and post-analytical issues regarding cfDNA tests. First, we summarized the characteristics of cfDNA and reviewed the methods used to identify tumor-derived cfDNA from the pool of total cfDNA. Second, we described the procedures used to extract cfDNA, which have a great impact on representativeness and yield. Finally, we discussed our thoughts on the validation of cfDNA-based tests and the reporting of test results amid drastic limitations.
  • 20.

    【2hr】Data analysis in the post-genome-wide association study era

    包量

    机译 后全基因组关联研究时代的数据分析
    摘要：Since the first report of a genome-wide association study (GWAS) on human age-related macular degeneration, GWAS has successfully been used to discover genetic variants for a variety of complex human diseases and/or traits, and thousands of associated loci have been identified. However, the underlying mechanisms for these loci remain largely unknown. To make these GWAS findings more useful, it is necessary to perform in-depth data mining. The data analysis in the post-GWAS era will include the following aspects: fine-mapping of susceptibility regions to identify susceptibility genes for elucidating the biological mechanism of action; joint analysis of susceptibility genes in different diseases; integration of GWAS, transcriptome, and epigenetic data to analyze expression and methylation quantitative trait loci at the whole-genome level, and find single-nucleotide polymorphisms that influence gene expression and DNA methylation; genome-wide association analysis of disease-related DNA copy number variations. Applying these strategies and methods will serve to strengthen GWAS data to enhance the utility and significance of GWAS in improving understanding of the genetics of complex diseases or traits and translate these findings for clinical applications.
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