T-cell receptor signal strength and epigenetic control of Bim predict memory CD8+ T-cell fate

摘要

Bim-mCherry mice faithfully report Bim expression levels. Representative histograms of Bim ICS and mCherry fluorescent intensities gated on C57BL/6 or Bim-mCherry reporter endogenous T or T cells. Plots are representative of three mice per group and repeated in two independent experiments. Bim ICS and mCherry fluorescent MFI levels. Bar graphs compare LCMV-specific CD8 terminal effector or pre-memory cells from LCMV-infected C57BL/6 (white bars,  = 3) or Bim-mCherry reporter (black bars,  = 4) mice measured on 10-day-post-infection (dpi). Results are representative of three independent experiments (mean ± SD, ***  t-test)