Mechanism of inhibition of mouse Slo3 (KCa5.1) potassium channels by quinine quinidine and barium

机译：奎宁奎尼丁和钡对小鼠Slo3（KCa5.1）钾通道的抑制作用机理

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Background and PurposeThe Slo3 (KCa5.1) channel is a major component of mammalian KSper (sperm potassium conductance) channels and inhibition of these channels by quinine and barium alters sperm motility. The aim of this investigation was to determine the mechanism by which these drugs inhibit Slo3 channels.

机译：背景和目的Slo3（KCa5.1）通道是哺乳动物KSper（精子钾电导）通道的主要组成部分，奎宁和钡对这些通道的抑制会改变精子的运动能力。这项研究的目的是确定这些药物抑制Slo3通道的机制。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
David C Wrighton; Stephen P Muench; Jonathan D Lippiat;
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作者单位

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年(卷),期 2015(172),17
年度 2015
页码 4355–4363
总页数 9
原文格式 PDF
正文语种
中图分类药学;
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专利

1. Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine [J] . Tang Qiong-Yao, Zhang Zhe, Xia Xiao-Ming, Channels . 2010,第1期

机译：CTX，IbTX，TEA，4-AP和奎尼丁对小鼠Slo1和Slo3 K +通道的阻断
2. Block of mouse Slo1 and Slo3 K+ channels by CTX, IbTX, TEA, 4-AP and quinidine [J] . Qiong-Yao Tang, Zhe Zhang, Xiao-Ming Xia, Channels . 2010,第1期

机译：CTX，IbTX，TEA，4-AP和奎尼丁对小鼠Slo1和Slo3 K +通道的阻断
3. Dual Mechanism for Inhibition of Inwardly Rectifying Kir2.x Channels by Quinidine Involving Direct Pore Block and PIP2-interference [J] . Koepple Christoph, Scherer Daniel, Seyler Claudia, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2017,第2期

机译：用于抑制喹吖啶植物直接孔径块和PIP2干扰的喹硫醌的向内整流Kir2.x通道的双重机制
4. Calcium-Activated Potassium Channels Inhibition in Autonomically Stimulated Human Atrial Myocytes [C] . Chiara Celotto, Carlos Sánchez, Pablo Laguna, Computing in Cardiology Conference . 2019

机译：钙激活钾通道抑制自主刺激的人类心房肌细胞。
5. Determinants of the pace, precision, and pattern of firing of subthalamic nucleus neurons in vitro: Contributions of small-conductance calcium -activated potassium channels and coupled voltage -gated calcium channels, and mechanisms of gamma-aminobutyric acid-mediated inhibition. [D] . Hallworth, Nicholas Emmanuel. 2004

机译：决定丘脑下丘脑神经元放电速度，精度和模式的因素：小电导钙激活钾通道和耦合电压门控钙通道的贡献，以及γ-氨基丁酸介导的抑制机制。
6. Block of mouse Slo1 and Slo3 K+ channels by CTX IbTX TEA 4-AP and quinidine [O] . Qiong-Yao Tang, Zhe Zhang, Xiao-Ming Xia, 2010

机译：CTXIbTXTEA4-AP和奎尼丁对小鼠Slo1和Slo3 K +通道的阻滞
7. Mechanism of inhibition of mouse Slo3 (KCa5.1) potassium channels by quinine, quinidine, and barium. [O] . Wrighton DC, Muench SP, Lippiat JD 2015

机译：奎宁，奎尼丁和钡抑制小鼠slo3（KCa5.1）钾通道的机制。
8. Regulation of C-myc Gene Expression by Potassium Channel Blocker Quinidine in MCF-7 Human Breast Cancer Cell Line [R] . Melkoumian, Z. 2002

机译：钾通道阻滞剂奎尼丁对mCF-7人乳腺癌细胞系C-myc基因表达的调控

Mechanism of inhibition of mouse Slo3 (KCa5.1) potassium channels by quinine quinidine and barium

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