Identification through high-throughput screening of 4-methoxyflavone and 34-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos

摘要

Background and PurposeThe current lack of disease-modifying therapeutics to manage neurological and neurodegenerative conditions justifies the development of more efficacious agents. One distinct pathway leading to neuronal death in these conditions and which represents a very promising and attractive therapeutic target is parthanatos, involving overactivation of PARP-1. We therefore sought to identify small molecules that could be neuroprotective by targeting the pathway.