A prolyl oligopeptidase inhibitor KYP-2047 reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinsons disease

机译：脯氨酰寡肽酶抑制剂KYP-2047可降低帕金森氏病细胞和动物模型中的α-突触核蛋白蛋白水平并聚集

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摘要

BACKGROUND AND PURPOSEThe aggregation of α-synuclein is connected to the pathology of Parkinson's disease and prolyl oligopeptidase (PREP) accelerates the aggregation of α-synuclein in vitro. The aim of this study was to investigate the effects of a PREP inhibitor, KYP-2047, on α-synuclein aggregation in cell lines overexpressing wild-type or A30P/A53T mutant human α-syn and in the brains of two A30P α-synuclein transgenic mouse strains.

机译：背景和目的α-突触核蛋白的聚集与帕金森氏病的病理学有关，脯氨酰寡肽酶（PREP）在体外促进α-突触核蛋白的聚集。这项研究的目的是研究PREP抑制剂KYP-2047对过表达野生型或A30P / A53T突变型人α-syn的细胞系以及两个A30Pα-突触核蛋白的脑中α-突触核蛋白聚集的影响转基因小鼠品系。

著录项

期刊名称 British Journal of Pharmacology and Chemotherapy
作者
TT Myöhänen; MJ Hannula; R Van Elzen; M Gerard; P Van Der Veken; JA García-Horsman; V Baekelandt; PT Männistö; AM Lambeir;
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作者单位

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年(卷),期 2012(166),3
年度 2012
页码 1097–1113
总页数 17
原文格式 PDF
正文语种
中图分类药学;
关键词
serine protease prolyl oligopeptidase inhibitor α-synuclein Parkinsons disease protein aggregation;

机译：丝氨酸蛋白酶;脯氨酰寡肽酶抑制剂;α-突触核蛋白;帕金森氏病;蛋白质聚集;

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专利

1. The beneficial effect of a prolyl oligopeptidase inhibitor, KYP-2047, on alpha-synuclein clearance and autophagy in A30P transgenic mouse [J] . Mari H. Savolainen, Christopher T. Richie, Bron K. Harvey, Neurobiology of disease . 2014,第Null期

机译：脯氨酰寡肽酶抑制剂，KYP-2047对A30P转基因小鼠α-突触核蛋白清除和自噬的有益作用
2. Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the alpha-Synuclein Virus Vector-Based Parkinson's Disease Mouse Model by Decreasing alpha-Synuclein Oligomeric Species in Mouse Brain [J] . Svarcbahs Reinis, Julku Ulrika H., Myohanen Timo T. The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2016,第49期

机译：通过减少小鼠脑中的α-突触核蛋白寡聚体，抑制脯氨酰寡肽酶可恢复基于α-突触核蛋白病毒载体的帕金森氏病小鼠模型中的自发运动行为。
3. PROLYL OLIGOPEPTIDASE COLOCALIZES WITH alpha-SYNUCLEIN, beta-AMYLOID, TAU PROTEIN AND ASTROGLIA IN THE POST-MORTEM BRAIN SAMPLES WITH PARKINSON'S AND ALZHEIMER'S DISEASES [J] . M. J. HANNULA, T. T. MYOHANEN, J. TENORIO-LARANGA, Neuroscience: An International Journal under the Editorial Direction of IBRO . 2013,第Null期

机译：帕金森氏病和老年痴呆症患者的早产儿样品中脯氨酰寡肽酶与α-突触核蛋白，β-淀粉样蛋白，Tau蛋白和天体质的关系
4. Raman imaging of α-synuclein aggregates in a rat model of Parkinson’s disease [C] . Eva Brauchle, Fide Sevgi, Daniel Carvajal Berrio, Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XVII . 2019

机译：帕金森氏病大鼠模型中α-突触核蛋白聚集体的拉曼成像
5. Role of the prolyl isomerase Pin1 in the pathogenesis of Parkinson's disease and neuroprotection by novel targeted compounds in pre-clinical animal models of the disease [D] . Ghosh, Anamitra 2012

机译：脯氨酰异构酶Pin1在帕金森氏病的发病机理和新型靶向化合物对神经疾病的临床前动物模型中的作用
6. Inhibition of Prolyl Oligopeptidase Restores Spontaneous Motor Behavior in the α-Synuclein Virus Vector–Based Parkinsons Disease Mouse Model by Decreasing α-Synuclein Oligomeric Species in Mouse Brain [O] . Reinis Svarcbahs, Ulrika H. Julku, Timo T. Myöhänen 2016

机译：抑制脯氨酰寡肽酶可通过减少小鼠脑中的α-突触核蛋白寡聚体来恢复基于α-突触核蛋白病毒载体的帕金森氏病小鼠模型中的自发运动行为
7. A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease [O] . Myöhänen, T T, Hannula, M J, Van Elzen, R, 2012

机译：脯氨酰寡肽酶抑制剂KYP-2047可降低帕金森氏病细胞和动物模型中的α-突触核蛋白蛋白水平并聚集

A prolyl oligopeptidase inhibitor KYP-2047 reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinsons disease

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