Bovine glycomacropeptide induces cytokine production in human monocytes through the stimulation of the MAPK and the NF-κB signal transduction pathways

机译：牛糖巨肽通过刺激MAPK和NF-κB信号转导途径诱导人单核细胞中细胞因子的产生

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Background and purpose:Bovine glycomacropeptide (BGMP) is a natural milk peptide that is produced naturally in the gastrointestinal tract during digestion. Glycomacropepide has intestinal anti-inflammatory activity, but the mechanism of action is unknown. Here we have characterized the effects of BGMP on monocytes.

机译：背景与目的：牛糖巨肽（BGMP）是一种天然的乳肽，在消化过程中会在胃肠道中自然产生。糖皮质激素肽具有肠抗炎活性，但作用机理尚不清楚。在这里，我们表征了BGMP对单核细胞的作用。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
Pilar Requena; Abdelali Daddaoua; Emilia Guadix; Antonio Zarzuelo; María Dolores Suárez; Fermín Sánchez de Medina; Olga Martínez-Augustin;
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作者单位

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年(卷),期 2009(157),7
年度 2009
页码 1232–1240
总页数 9
原文格式 PDF
正文语种
中图分类药学;
关键词
bovine glycomacropeptide THP-1 cells NF-κB;

机译：牛糖巨肽;THP-1细胞;NF-κB;

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2. Fusobacterium nucleatum Facilitates Apoptosis, ROS Generation, and Inflammatory Cytokine Production by Activating AKT/MAPK and NF-κB Signaling Pathways in Human Gingival Fibroblasts [J] . Wenyan Kang, Zhilong Jia, Di Tang, Oxidative Medicine and Cellular Longevity . 2019,第47期

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3. 7,8-Dihydroxyflavone attenuates the release of pro-inflammatory mediators and cytokines in lipopolysaccharide-stimulated BV2 microglial cells through the suppression of the NF-κB and MAPK signaling pathways [J] . ParkHye Young, ParkCheol, HwangHye Jin, International journal of molecular medicine . 2014,第4期

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4. cis-9, trans-11-Conjugated Linoleic Acid Exerts an Anti-inflammatory Effect in Bovine Mammary Epithelial Cells after Escherichia coli Stimulation through NF-κB Signaling Pathway [C] . Nana Ma, Guangjun Chang, Jie Huang, The 6th International Symposium on Dairy Cow Nutrition and Milk Quality（第六届“奶牛营养与牛奶质量”国际研讨会）论文集 . -1

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机译：循环拉伸力诱导牙周膜细胞分泌外来体，通过抑制巨噬细胞中的NF-κB信号通路抑制IL-1β的产生
6. Advanced Glycation End Products of Bovine Serum Albumin Suppressed Th1/Th2 Cytokine but Enhanced Monocyte IL-6 Gene Expression via MAPK-ERK and MyD88 Transduced NF-κB p50 Signaling Pathways [O] . Chieh-Yu Shen, Cheng-Han Wu, Cheng-Hsun Lu, 2019

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7. Bovine glycomacropeptide induces cytokine production in human monocytes through the stimulation of the MAPK and the NF-κB signal transduction pathways [O] . Requena, Pilar, Daddaoua, Abdelali, Guadix, Emilia, 2009

机译：牛糖巨肽通过刺激MAPK和NF-κB信号转导途径诱导人单核细胞中细胞因子的产生

Bovine glycomacropeptide induces cytokine production in human monocytes through the stimulation of the MAPK and the NF-κB signal transduction pathways

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