Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-κB-dependent iNOS and proinflammatory cytokines production

机译：抑制NF-κB依赖性iNOS和促炎性细胞因子产生的结果导致liquiritigenin的抗炎作用

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Background and purpose:Glycyrrhizae radix has been widely used as a cytoprotective, plant-derived medicine. We have identified a flavanoid, liquiritigenin, as an active component in extracts of Glycyrrhizae radix. This research investigated the effects of liquiritigenin on the induction of inducible NOS (iNOS) and proinflammatory cytokines by lipopolysaccharide (LPS) in Raw264.7 cells, and on paw oedema in rats.

机译：背景与目的：甘草已被广泛用作植物保护性细胞保护药物。我们已经确定了类黄酮，liquiritigenin，是甘草根提取物中的活性成分。这项研究调查了liquiritigenin对脂多糖（LPS）诱导Raw264.7细胞中诱导型NOS（iNOS）和促炎细胞因子的影响，以及对大鼠足水肿的影响。

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期刊名称 British Journal of Pharmacology and Chemotherapy
作者
Y W Kim; R J Zhao; S J Park; J R Lee; I J Cho; C H Yang; S G Kim; S C Kim;
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作者单位

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年(卷),期 2008(154),1
年度 2008
页码 165–173
总页数 9
原文格式 PDF
正文语种
中图分类药学;
关键词
liquiritigenin iNOS nuclear factor-κB TNF-α interleukin-1β interleukin-6;

机译：liquiritigenin;iNOS;核因子-κB;TNF-α;IL-1β;IL-6;

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1. NCS 613 exhibits anti-inflammatory effects on PBMCS from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production [J] . YougbaréI., BoireG., RoyM., Canadian Journal of Physiology and Pharmacology . 2013,第5期

机译：NCS 613通过抑制p38 MAPK和NF-κB信号通路同时减少促炎细胞因子的产生，对狼疮患者的PBMCS具有抗炎作用。
2. A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions. [J] . Guan-Jhong Huang, M Vijaya Bhaskar Reddy, Ping-Chung Kuo, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2012,第2期

机译：粘胶素的简明合成及其通过抑制iNOS，COX-2，ERK磷酸化和促炎细胞因子表达的抗炎作用。
3. A concise synthesis of viscolin, and its anti-inflammatory effects through the suppression of iNOS, COX-2, ERK phosphorylation and proinflammatory cytokines expressions. [J] . Guan-Jhong Huang, M Vijaya Bhaskar Reddy, Ping-Chung Kuo, European Journal of Medicinal Chemistry: Chimie Therapeutique . 2012,第2期

机译：通过抑制InOS，COX-2，ERK磷酸化和促炎细胞因子表达，简化了visclin的合成及其抗炎作用。
4. Proinflammatory and anti-inflammatory cytokines in vaccinated pigs subsequently exposed to PRRSV [C] . Martelli P., Ferrari L., Franceschi V., Congress ofthe International Pig Veterinary Society . 2008

机译：疫苗猪的促炎和抗炎细胞因子随后暴露于PRRSV
5. Effects of nicotine on behavior, proinflammatory cytokines, and brain derived neurotrophic factor in an animal model of depression [D] . Hauser, Sheketha R. 2006

机译：尼古丁对抑郁症动物模型中行为，促炎性细胞因子和脑源性神经营养因子的影响
6. Anti-Inflammatory Effects of Moxifloxacin on Activated Human Monocytic Cells: Inhibition of NF-κB and Mitogen-Activated Protein Kinase Activation and of Synthesis of Proinflammatory Cytokines [O] . Taly Weiss, Itamar Shalit, Hannah Blau, 2004

机译：莫西沙星对活化的人单核细胞的抗炎作用：抑制NF-κB和丝裂原活化的蛋白激酶的活化和促炎细胞因子的合成
7. Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-κB-dependent iNOS and proinflammatory cytokines production [O] . Kim, Y W, Zhao, R J, Park, S J, 2008

机译：抑制NF-κB依赖性iNOS和促炎性细胞因子产生的结果，导致liquiritigenin的抗炎作用

Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-κB-dependent iNOS and proinflammatory cytokines production

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