Photodynamic activity of BAM-SiPc an unsymmetrical bisamino silicon(IV) phthalocyanine in tumour-bearing nude mice

摘要

Background and purposeEver since the discovery of photodynamic therapy, there has been a continuous search for more potent photosensitizers. Towards that end, we have synthesized a number of novel phthalocyanine derivatives. The unsymmetrical bisamino silicon(IV) phthalocyanine BAM-SiPc is one of the most potent compounds. In in vitro cell culture, it exhibits high phototoxicity against a number of cancer cell lines.