A cholecystokinin-1 receptor agonist (CCK-8) mediates increased permeability of brain barriers to leptin

摘要

Background and purpose:Leptin regulates energy expenditure and body weight by acting both on the hypothalamus and on peripheral targets. Central actions of leptin are enhanced by cholecystokinin (CCK). The interaction between leptin and CCK makes physiological sense, as rats lacking CCK1 receptors are resistant to peripheral leptin but not to leptin directly infused into the brain. We have recently reported that CCK enhances leptin effects by increasing the entry of leptin into the CNS. The aim of this work was to further characterize the effect of CCK (10 μg kg⁻¹) on leptin kinetics as well as the CCK receptor subtype involved in the interaction between CCK and leptin.