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Mutagenicity studies in a tyre plant: in vitro activity of workers urinary concentrates and raw materials.

机译:轮胎厂的致突变性研究:工人尿液和原料的体外活性。

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摘要

The possible contribution to urinary mutagenicity of occupational exposures in the rubber industry was studied by assaying the urine concentrates of 72 workmen (44 smokers) employed in a tyre plant. Twenty three clerks (16 smokers) engaged in the administrative department of the same factory served as presumptive unexposed controls. XAD-2 resin concentrates of urine samples were assayed in the plate incorporation test and in the microtitre fluctuation assay with Salmonella typhimurium strains TA1535, TA98, and TA100. Furthermore, the in vitro mutagenicity of the major raw materials in use at the plant was determined in the plate incorporation assay with S typhimurium strains TA1535, TA1537, TA98, and TA100. The results obtained from the urinary mutagenicity study show that smoking habits, but not occupation, were statistically significantly related to the appearance of a urinary mutagenicity that was detectable with strain TA98. A possible synergistic effect of occupation with smoking was observed among tyre builders who were also smokers. The study of the raw materials showed that three technical grade materials were weakly active as mutagens in strain TA98 in the absence (poly-p-dinitrosobenzene) or in the presence of metabolic activation (mixed diaryl-p-phenylendiamines and tetramethyltiuram disulphide). The latter chemical was also weakly active in strain TA100.
机译:通过分析轮胎厂中72名工人(44名吸烟者)的尿液浓缩物,研究了橡胶行业中职业暴露对尿液致突变性的可能贡献。假定在同一工厂的行政部门的二十三名店员(十六名吸烟者)被用作未暴露的假定控制。用平板鼠伤寒沙门氏菌菌株TA1535,TA98和TA100在平板结合试验和微量滴定波动试验中测定尿液样品的XAD-2树脂浓缩物。此外,在鼠伤寒沙门氏菌菌株TA1535,TA1537,TA98和TA100的平板掺入测定中,确定了工厂中使用的主要原材料的体外诱变性。从尿液致突变性研究获得的结果表明,吸烟习惯而非职业与吸烟的致突变性的出现在统计学上显着相关,而TA98株可检测到。在也是吸烟者的轮胎制造商中,观察到吸烟与吸烟可能产生协同作用。对原材料的研究表明,三种工业级材料在不存在(聚对二亚硝基苯)或存在代谢活化(混合二芳基-对苯二胺和四甲基二铀)的情况下,在TA98菌株中均具有弱的诱变活性。后者在TA100菌株中也具有弱活性。

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