首页> 美国卫生研究院文献>BMJ Open Access >Tocilizumab discontinuation after attaining remission in patients with rheumatoid arthritis who were treated with tocilizumab alone or in combination with methotrexate: results from a prospective randomised controlled study (the second year of the SURPRISE study)

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Tocilizumab discontinuation after attaining remission in patients with rheumatoid arthritis who were treated with tocilizumab alone or in combination with methotrexate: results from a prospective randomised controlled study (the second year of the SURPRISE study)

机译：类风湿性关节炎患者单独或联合甲氨蝶呤治疗的类风湿关节炎患者达到缓解后停药：前瞻性随机对照研究（SURPRISE研究的第二年）

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ObjectiveTo evaluate the sustained remission and low disease activity after discontinuation of tocilizumab in patients with rheumatoid arthritis who were treated with tocilizumab alone or in combination with methotrexate.

机译：目的评估单独使用托珠单抗或与甲氨蝶呤联用治疗的类风湿关节炎患者在停用托珠单抗后持续缓解和疾病活动低。

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期刊名称 BMJ Open Access
作者
Yuko Kaneko; Masaru Kato; Yoshiya Tanaka; Masayuki Inoo; Hitomi Kobayashi-Haraoka; Koichi Amano; Masayuki Miyata; Yohko Murakawa; Hidekara Yasuoka; Shintaro Hirata; Eiichi Tanaka; Nobuyuki Miyasaka; Hisashi Yamanaka; Kazuhiko Yamamoto; Tsutomu Takeuchi;
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年(卷),期 -1(77),9
年度 -1
页码 1268–1275
总页数 8
原文格式 PDF
正文语种
中图分类
关键词
rheumatoid arthritis methotrexate dmards (biologic);

机译：类风湿关节炎;甲氨蝶呤;dmards（生物的）;

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专利

1. Tocilizumab discontinuation after attaining remission in patients with rheumatoid arthritis who were treated with tocilizumab alone or in combination with methotrexate: results from a prospective randomised controlled study (the second year of the SURPRISE study) [J] . Kaneko Yuko, Kato Masaru, Tanaka Yoshiya, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2018,第9期

机译：在患有类风湿性关节炎的患者中停留后停止康康替纳豆，单独或与甲氨蝶呤组合治疗：令人医前随机对照研究的结果（意外研究的第二年）
2. Comparison of adding tocilizumab to methotrexate with switching to tocilizumab in patients with rheumatoid arthritis with inadequate response to methotrexate: 52-week results from a prospective, randomised, controlled study (SURPRISE study) [J] . Kaneko Yuko, Atsumi Tatsuya, Tanaka Yoshiya, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2016,第11期

机译：类风湿关节炎对甲氨蝶呤反应不佳的患者中，在甲氨蝶呤中添加托珠单抗与切换至托珠单抗的比较：一项前瞻性，随机对照研究（SURPRISE研究）的52周结果
3. Clinical and structural remission rates increased annually and radiographic progression was continuously inhibited during a 3-year administration of tocilizumab in patients with rheumatoid arthritis: A multi-center, prospective cohort study by the Michinoku Tocilizumab Study Group [J] . Hirabayashi Yasuhiko, Munakata Yasuhiko, Miyata Masayuki, Modern rheumatology . 2016,第6期

机译：类风湿关节炎患者接受托珠单抗治疗3年期间，临床和结构缓解率逐年增加，放射学进展持续受到抑制：Michinoku Tocilizumab研究组进行的一项多中心，前瞻性队列研究
4. Early disease control by low-dose prednisone comedication may affect the quality of remission In patients with early rheumatoid arthritis [C] . Monica Todoerti, Carlo Alberto Scire, Nicola Boffini, International Conference on the Neuroendocrine Immune Basis of the Rheumatic Diseases . 2010

机译：低剂量泼尼松的早期疾病控制可能会影响早期类风湿性关节炎患者的缓解质量
5. Clinical studies of immunomodulatory activities of Yunzhi -Danshen in breast cancer and nasopharyngeal carcinoma patients, and Lingzhi-San Miao San in rheumatoid arthritis patients. [D] . Bao, Yixi. 2005

机译：云芝丹参对乳腺癌和鼻咽癌患者及类风湿关节炎灵芝三妙散的免疫调节活性的临床研究。
6. Extended report: Comparison of adding tocilizumab to methotrexate with switching to tocilizumab in patients with rheumatoid arthritis with inadequate response to methotrexate: 52-week results from a prospective randomised controlled study (SURPRISE study) [O] . Yuko Kaneko, Tatsuya Atsumi, Yoshiya Tanaka, -1

机译：扩展报告：类风湿关节炎对甲氨蝶呤反应不佳的患者中在甲氨蝶呤中添加托珠单抗与切换至托珠单抗的比较：一项前瞻性随机对照研究（SURPRISE研究）的52周结果
7. Tocilizumab combination therapy or monotherapy or methotrexate monotherapy in methotrexate-naive patients with early rheumatoid arthritis: 2-year clinical and radiographic results from the randomised, placebo-controlled FUNCTION trial [O] . Burmester, Gerd R., Rigby, William F., van Vollenhoven, Ronald F., 2017

机译：未接受甲氨蝶呤的类风湿关节炎患者接受Tocilizumab联合治疗或单药治疗或甲氨蝶呤单药治疗：随机，安慰剂对照FUNCTION试验的2年临床和影像学结果

Tocilizumab discontinuation after attaining remission in patients with rheumatoid arthritis who were treated with tocilizumab alone or in combination with methotrexate: results from a prospective randomised controlled study (the second year of the SURPRISE study)

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