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Effects of BI 655064 an antagonistic anti-CD40 antibody on clinical and biomarker variables in patients with active rheumatoid arthritis: a randomised double-blind placebo-controlled phase IIa study

机译：拮抗性抗CD40抗体BI 655064对活动性类风湿关节炎患者的临床和生物标志物变量的影响：一项随机双盲安慰剂对照的IIa期研究

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ObjectiveTo evaluate the safety, efficacy and therapeutic mechanism of BI 655064, an antagonistic anti-CD40 monoclonal antibody, in patients with rheumatoid arthritis (RA) and an inadequate response to methotrexate (MTX-IR).

机译：目的评估抗CD40单克隆抗体BI 655064在类风湿性关节炎（RA）和对甲氨蝶呤（MTX-IR）反应不足的患者中的安全性，疗效和治疗机制。

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期刊名称 BMJ Open Access
作者
Sudha Visvanathan; Stefan Daniluk; Rafał Ptaszyński; Ulf Müller-Ladner; Meera Ramanujam; Bernd Rosenstock; Anastasia G Eleftheraki; Richard Vinisko; Alena Petříková; Herbert Kellner; Eva Dokoupilova; Brygida Kwiatkowska; Rieke Alten; Christian Schwabe; Patrick Baum; David Joseph; Jay S Fine; Steven J Padula; Jürgen Steffgen;
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年(卷),期 -1(78),6
年度 -1
页码 754–760
总页数 7
原文格式 PDF
正文语种
中图分类
关键词
rheumatoid arthritis B-cells autoantibodies;

机译：类风湿关节炎;B细胞;自身抗体;

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1. Effects of BI 655064, an antagonistic anti-CD40 antibody, on clinical and biomarker variables in patients with active rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase IIa study [J] . Visvanathan Sudha, Daniluk Stefan, Ptaszynski Rafal, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2019,第6期

机译：抗拮抗抗CD40抗体，抗拮抗抗CD40抗体，在活性类风湿性关节炎患者中的临床和生物标志物变量：随机，双盲，安慰剂控制，IIA研究
2. Effect of denosumab on Japanese patients with rheumatoid arthritis: a dose-response study of AMG 162 (Denosumab) in patients with RheumatoId arthritis on methotrexate to Validate inhibitory effect on bone Erosion (DRIVE)-a 12-month, multicentre, randomised, double-blind, placebo-controlled, phase II clinical trial [J] . Takeuchi Tsutomu, Tanaka Yoshiya, Ishiguro Naoki, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2016,第6期

机译：地诺单抗对日本类风湿性关节炎患者的影响：甲氨蝶呤风湿性关节炎患者中AMG 162（Denosumab）的剂量反应研究，以验证其对骨侵蚀（DRIVE）的抑制作用-12个月，多中心，随机，双盲目，安慰剂对照，II期临床试验
3. MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised, double-blind, placebo-controlled, dose-escalation trial [J] . Behrens Frank, Tak Paul P., Ostergaard Mikkel, Annals of the Rheumatic Diseases: A Journal of Clinical Rheumatology and Connective Tissue Research . 2015,第6期

机译：MOR103，一种针对粒细胞巨噬细胞集落刺激因子的人单克隆抗体，在中度类风湿关节炎患者的治疗中：Ib / IIa期随机，双盲，安慰剂对照，剂量递增试验的结果
4. Clinical studies of immunomodulatory activities of Yunzhi -Danshen in breast cancer and nasopharyngeal carcinoma patients, and Lingzhi-San Miao San in rheumatoid arthritis patients. [D] . Bao, Yixi. 2005

机译：云芝丹参对乳腺癌和鼻咽癌患者及类风湿关节炎灵芝三妙散的免疫调节活性的临床研究。
5. Extended report: MOR103 a human monoclonal antibody to granulocyte–macrophage colony-stimulating factor in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib/IIa randomised double-blind placebo-controlled dose-escalation trial [O] . Frank Behrens, Paul P Tak, Mikkel Østergaard, -1

机译：扩展报告：MOR103一种针对粒细胞-巨噬细胞集落刺激因子的人单克隆抗体在中度类风湿关节炎患者的治疗中：Ib / IIa期随机双盲安慰剂对照剂量递增试验的结果
6. Effects of BI 655064, an antagonistic anti-CD40 antibody, on clinical and biomarker variables in patients with active rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase IIa study [O] . Sudha Visvanathan, Stefan Daniluk, Rafał Ptaszyński, 2019

机译：抗拮抗抗CD40抗体，患者对患者的临床和生物标志物变量的影响：随机，双盲，安慰剂控制，相IIA研究

Effects of BI 655064 an antagonistic anti-CD40 antibody on clinical and biomarker variables in patients with active rheumatoid arthritis: a randomised double-blind placebo-controlled phase IIa study

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