MicroRNA-374a -4680 and -133b suppress cell proliferation through the regulation of genes associated with human cleft palate in cultured human palate cells

摘要

BackgroundCleft palate (CP) is the second most common congenital birth defect; however, the relationship between CP-associated genes and epigenetic regulation remains largely unknown. In this study, we investigated the contribution of microRNAs (miRNAs) to cell proliferation and regulation of genes involved in CP development.