Ginsenosides induce extensive changes in gene expression and inhibit oxidative stress-induced apoptosis in human lens epithelial cells

摘要

Ginsenoside reverses H O -induced growth inhibition of HLE-B3 cells. HLE-B3 cells were treated with 1.75 μM H O and low (5 μM), mid (10 μM) and high dose (20 μM) of ginsenoside. Viabilities of HLE-B3 cells were examined by MTT assays as detailed in Methods. Ginsenoside significantly alleviated the growth inhibitory effect of H O on HLE-B3 cells with more than 3-fold increase in the percentage of viable HLE-B3 cells. No statistical difference was observed in the percentage of viable HLE-B3 cells treated with low (5 μM), mid (10 μM) and high dose (20 μM) of ginsenoside (  > 0.05)