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  • 刊频： Three no. a year, <2006->
  • NLM标题： Biochem Med (Zagreb)
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共438条结果
  • 1.

    【2hr】Impact of reference change value (RCV) based autoverification on turnaround time and physician satisfaction

    包量

    机译 基于参考更改值（RCV）的自动验证对周转时间和医师满意度的影响
    摘要：BackgroundFor a quicker delivery of laboratory test results to the hospital emergency department (ED), we implemented an autoverification system based on the reference change value (RCV). The aim of this study was to assess how the RCV based autoverification reflected on turnaround time (TAT) and on physician satisfaction.
  • 2.

    【2hr】Survival analysis, more than meets the eye

    包量

    机译 生存分析，超越眼界
    摘要：The log-rank test is a cornerstone of phase III oncology clinical trials. However, there are at least three different mathematical procedures that can be named the log-rank test and two of them are widely used by commercial statistical programs. Consequently, different P values can be obtained. In the case of a borderline statistical significance, this can mean the difference between the evidence (significant P value) and merely an observation. Since all three methods can be reported under the same name, space for possible data manipulation occurs. This should be of a particular concern in a drug regulatory context. Randomized clinical trials with borderline significant results should perhaps be required to report P values calculated by all three methods, in order to properly evaluate drug efficacy. An interactive MS Excel spreadsheet that uses all three logrank test variants is prepared as a supplementary file accompanying this article. Association of high grade of bone marrow fibrosis with poor outcome in patients with myelofibrosis is used as an example.
  • 3.

    【2hr】A nationwide multicentre study in Turkey for establishing reference intervals of haematological parameters with novel use of a panel of whole blood

    包量

    机译 土耳其的一项全国性多中心研究，旨在通过新颖使用全血样本建立血液学参数参考区间
    摘要：IntroductionA nationwide multicentre study was conducted to establish well-defined reference intervals (RIs) of haematological parameters for the Turkish population in consideration of sources of variation in reference values (RVs).
  • 4.

    【2hr】Special issue on External Quality Assessment in Laboratory Medicine – current challenges and future trends

    包量

    机译 检验医学外部质量评估特刊-当前的挑战和未来的趋势
    摘要：
  • 5.

    【2hr】Labile glycated haemoglobin and carbamylated haemoglobin are still critical points for HbA1c measurement

    包量

    机译 不稳定的糖化血红蛋白和氨基甲酸酯化的血红蛋白仍然是HbA1c测量的关键点
    摘要：IntroductionHaemoglobin A1c (HbA1c) is a key analyte for the monitoring of glycemic balance in diabetic patients and is used for diabetes diagnosis in many countries. The potential interference of carbamylated haemoglobin (cHb) and labile glycated haemoglobin (LA1c) on HbA1c assays must remain a matter of vigilance. Such a situation has occurred in our laboratory with a kit replacement on the Bio-Rad Variant™ II testing system, a cation-exchange high performance liquid chromatography (HPLC) system. With this method, LA1c and cHb coeluted in a same peak which may have different consequences on HbA1c values.
  • 6.

    【2hr】The role of EQA in harmonization in laboratory medicine – a global effort

    包量

    机译 EQA在实验室医学协调中的作用–全球努力
    摘要：There are many activities currently being undertaken in the field of laboratory medicine under the broad heading of “harmonization”. These include traceability of results to international reference standards, processes to align results from assays where traceability has not been achieved (analytical harmonization) and international or national clinical guidelines based on studies from many parts of the world. Many of these issues are global in nature, with clinical evidence derived from studies performed in all parts of the world and multinational diagnostic companies providing assays worldwide. As with all aspects of medicine, progress can only be assured where these is evidence of effectiveness of the activities. External Quality Assurance (EQA) programs are designed to meet this need. Currently EQA processes have significant limitations in meeting the global needs of the laboratory medicine community. This paper aims to identify the steps that can be taken to allow current and future EQA programs to provide information on global variation in results. It is only by being aware of result differences that steps can be taken to improve performance.
  • 7.

    【2hr】Evaluation of staff performance and interpretation of the screening program for prevention of thalassemia

    包量

    机译 评估员工绩效并解释预防地中海贫血的筛查计划
    摘要：IntroductionThalassemia screening program has been implemented for years in Southeast Asia, but no external quality assessment program has been established. We have developed and initiated the proficiency testing (PT) program for the first time in Thailand with the aim to assess the screening performance of laboratory staff and their competency in interpretation of the screening results.
  • 8.

    【2hr】An overview of the European Organization for External Quality Assurance Providers in Laboratory Medicine (EQALM)

    包量

    机译 欧洲实验室医学外部质量保证提供者组织（EQALM）概述
    摘要：The European Organisation for External Quality Assurance Providers in Laboratory Medicine (EQALM) was founded in 1996 and currently has members from 29 European countries and 6 countries from outside Europe. EQALM provides a forum for co-operation and exchange of knowledge on quality-related matters in laboratory medicine, especially with regard to external quality assessment (EQA) programs in Europe. In addition, EQALM represent the EQA providers in laboratory medicine at European level vis-ŕ-vis political, professional, scientific and other bodies, including patients’ organisations. To this end EQALM promotes activities such as organizing meetings with scientific and practical themes for members and other interested parties, issuing scientific publications, developing EQA projects and representing laboratory medicine EQA activities within other organisations and networks. EQALM is active in scientific and educational activity in different fields such as survey frequency, haematology, haemostasis, microbiology, nomenclature, virtual microscopy, traceability, accreditation, and quality assurance of the total testing process. The aim of this paper is to give an overview of the EQALM organisation.
  • 9.

    【2hr】The alcohol used for cleansing the venipuncture site does not jeopardize blood and plasma alcohol measurement with head-space gas chromatography and an enzymatic assay

    包量

    机译 用于清洗静脉穿刺部位的酒精不会危害通过顶空气相色谱法和酶促测定法测定血液和血浆酒精
    摘要：IntroductionThis study aimed to establish whether an alcoholic antiseptic, wiped or not before venipuncture, may jeopardize alcohol testing with a commercial enzymatic assay and a reference head-space gas chromatography (GC) technique.
  • 10.

    【2hr】Demystifying EQA statistics and reports

    包量

    机译 揭开EQA统计数据和报告的神秘面纱
    摘要：Reports act as an important feedback tool in External Quality Assessment (EQA). Their main role is to score laboratories for their performance in an EQA round. The most common scores that apply to quantitative data are Q- and Z-scores. To calculate these scores, EQA providers need to have an assigned value and standard deviation for the sample. Both assigned values and standard deviations can be derived chemically or statistically. When derived statistically, different anomalies against the normal distribution of the data have to be handled. Various procedures for evaluating laboratories are able to handle these anomalies. Formal tests and graphical representation techniques are discussed and suggestions are given to help choosing between the different evaluations techniques. In order to obtain reliable estimates for calculating performance scores, a satisfactory number of data is needed. There is no general agreement about the minimal number that is needed. A solution for very small numbers is proposed by changing the limits of evaluation.
    Apart from analyte- and sample-specific laboratory evaluation, supplementary information can be obtained by combining results for different analytes and samples. Various techniques are overviewed. It is shown that combining results leads to supplementary information, not only for quantitative, but also for qualitative and semi-quantitative analytes.
  • 11.

    【2hr】Topiramate induced metabolic acidosis and kidney stones – a case study

    包量

    机译 托吡酯引起的代谢性酸中毒和肾结石–案例研究
    摘要：IntroductionThe aim of this study is to present a case of 44 years old woman with topiramate induced metabolic acidosis and kidney stones.
  • 12.

    【2hr】Interpretation of EQA results and EQA-based trouble shooting

    包量

    机译 解释EQA结果和基于EQA的故障排除
    摘要：Important objectives of External Quality Assessment (EQA) is to detect analytical errors and make corrective actions. The aim of this paper is to describe knowledge required to interpret EQA results and present a structured approach on how to handle deviating EQA results. The value of EQA and how the EQA result should be interpreted depends on five key points: the control material, the target value, the number of replicates, the acceptance limits and between lot variations in reagents used in measurement procedures. This will also affect the process of finding the sources of errors when they appear. The ideal EQA sample has two important properties: it behaves as a native patient sample in all methods (is commutable) and has a target value established with a reference method. If either of these two criteria is not entirely fulfilled, results not related to the performance of the laboratory may arise. To help and guide the laboratories in handling a deviating EQA result, the Norwegian Clinical Chemistry EQA Program (NKK) has developed a flowchart with additional comments that could be used by the laboratories e.g. in their quality system, to document action against deviations in EQA. This EQA-based trouble-shooting tool has been developed further in cooperation with the External quality Control for Assays and Tests (ECAT) Foundation. This flowchart will become available in a public domain, i.e. the website of the European organisation for External Quality Assurance Providers in Laboratory Medicine (EQALM).
  • 13.

    【2hr】Detection of let-7 miRNAs in urine supernatant as potential diagnostic approach in non-metastatic clear-cell renal cell carcinoma

    包量

    机译 检测尿上清液中let-7 miRNAs作为非转移性透明细胞肾细胞癌的潜在诊断方法
    摘要：IntroductionUrinary microRNAs (miRNAs) are emerging as a clinically useful tool for early and non-invasive detection of various types of cancer. The aim of this study was to evaluate whether let-7 family miRNAs differ in their urinary concentrations between renal cell carcinoma (RCC) cases and healthy controls.
  • 14.

    【2hr】Survey material choices in haematology EQA: a confounding factor in automated counting performance assessment

    包量

    机译 血液学EQA中的调查材料选择：自动计数性能评估中的一个混杂因素
    摘要：The complete blood count (CBC) is one of the most frequently requested tests in laboratory medicine, performed in a range of healthcare situations. The provision of an ideal assay material for external quality assessment is confounded by the fragility of the cellular components of blood, the lack of commutability of stabilised whole blood material and the lack of certified reference materials and methods to which CBC results can be traced. The choice of assay material between fresh blood, extended life assay material and fully stabilised, commercially prepared, whole blood material depends upon the scope and objectives of the EQA scheme. The introduction of new technologies in blood counting and the wider clinical application of parameters from the extended CBC will bring additional challenges for the EQA provider.
  • 15.

    【2hr】Biochemia Medica introduces new section: Pre-analytical mysteries

    包量

    机译 Medica Biochemia引入了新的部分：分析前的奥秘
    摘要：
  • 16.

    【2hr】External Quality Assessment beyond the analytical phase: an Australian perspective

    包量

    机译 分析阶段之后的外部质量评估：澳大利亚的观点
    摘要：External Quality Assessment (EQA) is the verification, on a recurring basis, that laboratory results conform to expectations for the quality required for patient care. It is now widely recognised that both the pre- and post-laboratory phase of testing, termed the diagnostic phases, are a significant source of laboratory errors. These errors have a direct impact on both the effectiveness of the laboratory and patient safety. Despite this, Australian laboratories tend to be focussed on very narrow concepts of EQA, primarily surrounding test accuracy, with little in the way of EQA programs for the diagnostic phases. There is a wide range of possibilities for the development of EQA for the diagnostic phases in Australia, such as the utilisation of scenarios and health informatics. Such programs can also be supported through advances in health information and communications technology, including electronic test ordering and clinical decision support systems. While the development of such programs will require consultation and support from the referring doctors, and their format will need careful construction to ensure that the data collected is de-identified and provides education as well as useful and informative data, we believe that there is high value in the development of such programs. Therefore, it is our opinion that all pathology laboratories should strive to be involved in an EQA program in the diagnostic phases to both monitor the diagnostic process and to identify, learn from and reduce errors and near misses in these phases in a timely fashion.
  • 17.

    【2hr】Acutely developing, spurious anaemia without actual blood loss. A paradigmatic case report

    包量

    机译 急性发展的假性贫血，无实际失血。案例报告
    摘要：We describe the case of a 55-year old women admitted at night to the emergency department (ED), complaining for acute abdominal pain lasting for nearly 5 hours. A first blood testing, performed immediately after admission, revealed mild anaemia. A second blood sample, drawn two hours after admission, revealed a considerable decrease of haemoglobin, haematocrit, total white blood cell and platelet counts (between 10-15% reduction). Abdominal ultrasonography was normal and the patient had no signs or symptoms of internal or external haemorrhage. Pre-analytical and analytical errors were accurately excluded. No infusion therapy was administered. After thoughtful discussing the sequence of events, it was ascertained that the first set of blood samples was drawn with the patient in seated position, immediately after ED admission (i.e., approximately 1 min passed from standing to seated position before venipuncture), whereas the second set of blood samples was drawn with the patient lying for two hours in supine position. This case report highlights the importance of standardizing patient position before venous blood collection, along with the crucial role played by cooperation and communication between laboratory and clinical wards for identifying and troubleshooting potential causes of spurious results of in vitro diagnostic testing.
  • 18.

    【2hr】Essential aspects of external quality assurance for point-of-care testing

    包量

    机译 即时检验的外部质量保证的基本方面
    摘要：External quality assurance (EQA) or proficiency testing for point-of-care (POC) testing is in principle similar to EQA for larger hospital laboratories, but the participants are different. The participants are usually health care personnel with little or no knowledge of laboratory medicine. The implication of this is that the EQA provider has to a) convince the participants that participation in EQA schemes are important, b) be able to circulate materials with reasonable time intervals, c) produce feedback reports that are understandable, and d) offer help and guidance to the participants when needed. It is also important that EQA for POC testing e) address the pre-examination, the examination and the post-examination processes, and f) that schemes for measurement procedures using interval or ordinal scale are offered. The aim of the present paper is to highlight important issues of these essential aspects of EQA for POC testing.
  • 19.

    【2hr】Case report of unexplained hypocalcaemia in a slightly haemolysed sample

    包量

    机译 轻微溶血的样本中原因不明的低钙血症的病例报告
    摘要：The case presented highlights a common pre-analytical problem identified in the laboratory that was initially missed. It concerns a young, generally healthy adult patient with no significant medical history and no significant family history. They presented with common flu like symptoms to their primary care clinician who considered this was most likely a viral problem that would pass with time. The clinician, however, did some routine bloods to reassure the patient despite a lack of clinical indication. When the sample was analysed the sample was haemolysed with strikingly low calcium. This led to the patient being called into hospital for urgent repeat investigations, all of which turned out to be within normal ranges. On further investigation the original sample was found to be contaminated. This result would normally have been flagged but was missed due to the complication of haemolysis.
  • 20.

    【2hr】External Quality Assessment in Croatia: problems, challenges, and specific circumstances

    包量

    机译 克罗地亚的外部质量评估：问题，挑战和特殊情况
    摘要：In Croatian medical laboratories (ML), external quality assessment (EQA) has a long tradition of almost half of a century. At national level, EQA is provided by Croatian Centre for Quality Assessment in Laboratory Medicine (CROQALM) which is a part of Croatian Society of Medical Biochemistry and Laboratory Medicine.
    This case study aimed to summarize the main challenges, which are set to CROQALM and their possible solutions.
    CROQALM has 10 schemes, covering majority of analysis for which medical biochemistry laboratories in Croatia are authorized for, including pre-analytical and post-analytical phase of laboratory work. Assessment scheme has three exercises per year. One sample per scheme and exercise is distributed to participants depending on their application. All data transfer and evaluation of the results are done using web interface and statistical software for evaluation of quality in laboratory medicine.
    Since CROQALM has relatively small number of participating laboratories (N = 197) with lot of different manufacturers of instruments used for analysis in all schemes, constant challenges are present in the evaluation of the results (commutability problems, statistical analysis etc.). Further, number of participating medical laboratories is even lower for highly specific parameters, which are in the scope of clinical laboratories only.
    Despite the obstacles we are faced to, EQA at national level is useful tool regarding standardization and harmonization aspects in total testing process within the country. Furthermore, it gives participating laboratories recognition and proof for meeting expected quality criteria in the community they serve.
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