A2A and A3 adenosine receptor expression in rheumatoid arthritis: upregulation inverse correlation with disease activity score and suppression of inflammatory cytokine and metalloproteinase release

摘要

IntroductionThe reduction of the inflammatory status represents one of the most important targets in rheumatoid arthritis (RA). A central role of A2A and A3 adenosine receptors (ARs) in mechanisms of inflammation has been reported in different pathologies. The primary aim of this study was to investigate the A2A and A3ARs and their involvement in RA progression measured by Disease Activity Score in 28 or 44 joints (DAS28 or DAS).