Negative association of the chemokine receptor CCR5 d32 polymorphism with systemic inflammatory response extra-articular symptoms and joint erosion in rheumatoid arthritis

摘要

IntroductionChemokines and their receptors control immune cell migration during infections as well as in autoimmune responses. A 32 bp deletion in the gene of the chemokine receptor CCR5 confers protection against HIV infection, but has also been reported to decrease susceptibility to rheumatoid arthritis (RA). The influence of this deletion variant on the clinical course of this autoimmune disease was investigated.