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Pontine haemorrhage mimicked by an olanzapine overdose

机译:过量服用奥氮平模拟肌出血

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摘要

Olanzapine, an atypical antipsychotic of the thienobenzodiazepine class, has been on the market since 1996. Its popularity has increased over recent years because of excellent clinical results as well as a favourable side effect profile. Mirroring this increased olanzapine use has been a rise in the number of non‐accidental overdoses. The clinical picture of olanzapine overdose can be surprisingly variable. In the case presented, the patient's low Glasgow Coma Score prevented an accurate history being taken. Examination revealed bilateral upgoing plantars, pinpoint pupils, increased tone, and brisk reflexes; however initial investigations, including an urgent CT head, were normal. The patient required 24 hours of intensive care before he regained consciousness and admitted to the overdose. Although there are several reports of olanzapine mimicking opiate intoxication in overdose, this is one of the first cases where overdose has mimicked an intracerebral event. The authors highlight some of the literature regarding clinical presentation and treatment options, and discuss the relation between olanzapine therapy and diabetes.
机译:自1996年以来,奥氮平(一种非典型的噻吩并二氮杂卓类抗精神病药)开始投放市场。近年来,由于出色的临床效果以及良好的副作用,其受欢迎程度有所提高。反映出这种增加的奥氮平使用率的是非偶然用药过量的增加。奥氮平过量的临床表现可能令人惊讶地变化。在出现的情况下,患者的格拉斯哥昏迷评分低,无法准确记录病史。检查发现双侧足底bilateral直,瞳孔细小,语气增强,反射活跃。但是,包括紧急CT头在内的初步检查是正常的。患者需要24小时的重症监护才能恢复知觉并服药过量。尽管有几项奥氮平模仿过量服用鸦片中毒的报道,但这是过量服用模仿脑内事件的首批病例之一。作者重点介绍了有关临床表现和治疗选择的一些文献,并讨论了奥氮平治疗与糖尿病之间的关系。

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