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NOVEL POLYMORPH 'FORM E ' OF OLANZAPINE (2-METHYL-4- (4-METHYL-1-PIPERAZINYL) -10H-THIENO 2, 3-B 1, 5 BENZODIAZEPINE) AND PREPARATION OF THE ANHYDROUS NON-SOLVATED CRYSTALLINE POLYMORPHIC 'FORM I' OF OLANZAPINE FROM THE POLYMORPHIC OLANZAPINE 'FORM E'
NOVEL POLYMORPH 'FORM E ' OF OLANZAPINE (2-METHYL-4- (4-METHYL-1-PIPERAZINYL) -10H-THIENO 2, 3-B 1, 5 BENZODIAZEPINE) AND PREPARATION OF THE ANHYDROUS NON-SOLVATED CRYSTALLINE POLYMORPHIC 'FORM I' OF OLANZAPINE FROM THE POLYMORPHIC OLANZAPINE 'FORM E'
The invention provides an Olanzapine pseudopolymoph Form E. The invention provides methods of preparing polymorphic Olanzapine Form E employing rapid crystallization and seeding. The invention provides methods of preparing anhydrous Olanzapine Form I from the Olanzapine Form E by step-wise drying.
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