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  • 刊频： Weekly, 1986-
  • NLM标题： Appl Phys Lett
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共441条结果
  • 1.

    【2hr】Continuous-flow multi-pulse electroporation at low DC voltages by microfluidic flipping of the voltage space topology

    包量

    机译 通过电压空间拓扑的微流体翻转在低直流电压下进行连续流多脉冲电穿孔
    摘要：Concerns over biosafety, cost, and carrying capacity of viral vectors have accelerated research into physical techniques for gene delivery such as electroporation and mechanoporation. Advances in microfabrication have made it possible to create high electric fields over microscales, resulting in more efficient DNA delivery and higher cell viability. Continuous-flow microfluidic methods are typically more suitable for cellular therapies where a large number of cells need to be transfected under sterile conditions. However, the existing continuous-flow designs used to generate multiple pulses either require expensive peripherals such as high-voltage (>400 V) sources or function generators, or result in reduced cell viability due to the proximity of the cells to the electrodes. In this paper, we report a continuous-flow microfluidic device whose channel geometry reduces instrumentation demands and minimizes cellular toxicity. Our design can generate multiple pulses of high DC electric field strength using significantly lower voltages (15–60 V) than previous designs. The cells flow along a serpentine channel that repeatedly flips the cells between a cathode and an anode at high throughput. The cells must flow through a constriction each time they pass from an anode to a cathode, exposing them to high electric field strength for short durations of time (the “pulse-width”). A conductive biocompatible poly-aniline hydrogel network formed in situ is used to apply the DC voltage without bringing the metal electrodes close to the cells, further sheltering cells from the already low voltage electrodes. The device was used to electroporate multiple cell lines using electric field strengths between 700 and 800 V/cm with transfection efficiencies superior than previous flow-through designs.
  • 2.

    【2hr】Flexible bottom-gate graphene transistors on Parylene C substrate and the effect of current annealing

    包量

    机译 聚对二甲苯C衬底上的柔性底栅石墨烯晶体管和电流退火的影响
    摘要：Flexible graphene transistors built on a biocompatible Parylene C substrate would enable active circuitry to be integrated into flexible implantable biomedical devices. An annealing method to improve the performance of a flexible transistor without damaging the flexible substrate is also desirable. Here, we present a fabrication method of a flexible graphene transistor with a bottom-gate coplanar structure on a Parylene C substrate. Also, a current annealing method and its effect on the device performance have been studied. The localized heat generated by the current annealing method improves the drain current, which is attributed to the decreased contact resistance between graphene and S/D electrodes. A maximum current annealing power in the Parylene C-based graphene transistor has been extracted to provide a guideline for an appropriate current annealing. The fabricated flexible graphene transistor shows a field-effect mobility, maximum transconductance, and a Ion/Ioff ratio of 533.5 cm2/V s, 58.1 μS, and 1.76, respectively. The low temperature process and the current annealing method presented here would be useful to fabricate two-dimensional materials-based flexible electronics.
  • 3.

    【2hr】Synchronization of Clocks Through 12 km of Strongly Turbulent Air Over a City

    包量

    机译 通过城市上空12公里的强烈湍流使时钟同步
    摘要：We demonstrate real-time, femtosecond-level clock synchronization across a low-lying, strongly turbulent, 12-km horizontal air path by optical two-way time transfer. For this long horizontal free-space path, the integrated turbulence extends well into the strong turbulence regime corresponding to multiple scattering with a Rytov variance up to 7 and with the number of signal interruptions exceeding 100 per second. Nevertheless, optical two-way time transfer is used to synchronize a remote clock to a master clock with femtosecond-level agreement and with a relative time deviation dropping as low as a few hundred attoseconds. Synchronization is shown for a remote clock based on either an optical or microwave oscillator and using either tip-tilt or adaptive-optics free-space optical terminals. The performance is unaltered from optical two-way time transfer in weak turbulence across short links. These results confirm that the two-way reciprocity of the free-space time-of-flight is maintained both under strong turbulence and with the use of adaptive optics. The demonstrated robustness of optical two-way time transfer against strong turbulence and its compatibility with adaptive optics is encouraging for future femtosecond clock synchronization over very long distance ground-to-air free-space paths.
  • 4.

    【2hr】Structural analysis of the epitaxial interface Ag/ZnO in hierarchical nanoantennas

    包量

    机译 分层纳米天线中外延界面Ag / ZnO的结构分析
    摘要：Detectors, photo-emitter, and other high order radiation devices work under the principle of directionality to enhance the power of emission/transmission in a particular direction. In order to understand such directionality, it is important to study their coupling mechanism of their active elements. In this work, we present a crystalline orientation analysis of ZnO nanorods grown epitaxially on the pentagonal faces of silver nanowires. The analysis of the crystalline orientation at the metal-semiconductor interface (ZnO/Ag) is performed with precession electron diffraction under assisted scanning mode. In addition, high resolution X-ray diffraction on a Bragg-Brentano configuration has been used to identify the crystalline phases of the arrangement between ZnO rods and silver nanowires. The work presented herein provides a fundamental knowledge to understand the metal-semiconductor behavior related to the receiving/transmitting mechanisms of ZnO/Ag nanoantennas.
  • 5.

    【2hr】Influence of internal geometry on magnetization reversal in asymmetric permalloy rings

    包量

    机译 内部几何形状对不对称坡莫合金环中磁化反转的影响
    摘要：We report the magnetization reversal behavior of microstructured Ni80Fe20 rings using magneto-optic indicator film imaging and magnetometry. While the reversal behavior of rings with a symmetric (circular) interior hole agrees with micromagnetic simulations of an onion → vortex → onion transition, we experimentally demonstrate that rings possessing an elliptical hole with an aspect ratio of 2 exhibit complex reversal behavior comprising incoherent domain propagation in the rings. Magneto optic images reveal metastable magnetic configurations that illustrate this incoherent behavior. These results have important implications for understanding the reversal behavior of asymmetric ferromagnetic rings.
  • 6.

    【2hr】Porous photonic crystal external cavity laser biosensor

    包量

    机译 多孔光子晶体外腔激光生物传感器
    摘要：We report the design, fabrication, and testing of a photonic crystal (PC) biosensor structure that incorporates a porous high refractive index TiO2 dielectric film that enables immobilization of capture proteins within an enhanced surface-area volume that spatially overlaps with the regions of resonant electromagnetic fields where biomolecular binding can produce the greatest shifts in photonic crystal resonant wavelength. Despite the nanoscale porosity of the sensor structure, the PC slab exhibits narrowband and high efficiency resonant reflection, enabling the structure to serve as a wavelength-tunable element of an external cavity laser. In the context of sensing small molecule interactions with much larger immobilized proteins, we demonstrate that the porous structure provides 3.7× larger biosensor signals than an equivalent nonporous structure, while the external cavity laser (ECL) detection method provides capability for sensing picometer-scale shifts in the PC resonant wavelength caused by small molecule binding. The porous ECL achieves a record high figure of merit for label-free optical biosensors.
  • 7.

    【2hr】Lock-in camera based heterodyne holography for ultrasound-modulated opticaltomography inside dynamic scattering media

    包量

    机译 基于锁定相机的外差全息术，用于超声调制光学动态散射介质内部的层析成像
    摘要：Ultrasound-modulated optical tomography (UOT) images optical contrast deep inside scattering media. Heterodyne holography based UOT is a promising technique that uses a camera for parallel speckle detection. In previous works, the speed of data acquisition was limited by the low frame rates of conventional cameras. In addition, when the signal-to-background ratio was low, these cameras wasted most of their bits representing an informationless background, resulting in extremely low efficiencies in the use of bits. Here, using a lock-in camera, we increase the bit efficiency and reduce the data transfer load by digitizing only the signal after rejecting the background. Moreover, compared with the conventional four-frame based amplitude measurement method, our single-frame method is more immune to speckle decorrelation. Using lock-in camera based UOT with an integration time of 286 μs, we imaged an absorptive object buried inside a dynamic scattering medium exhibiting a speckle correlation time (τc) as short as 26 μs. Since our method cantolerate speckledecorrelationfaster than that found in living biological tissue (τc ∼ 100–1000 μs), it is promising forin vivo deep tissue non-invasive imaging.
  • 8.

    【2hr】Switching 70Pb(Mg1/3Nb2/3)O3-0.30PbTiO3 single crystal by 3 MHz bipolar field

    包量

    机译 通过3 MHz双极场切换70Pb（Mg1 / 3Nb2 / 3）O3-0.30PbTiO3单晶
    摘要：Polarization switching and associated electromechanical property changes at 3.0 MHz were investigated with and without a direct current (dc) bias for [001]c poled 0.70Pb(Mg1/3Nb2/3)O3-0.30PbTiO3 single crystal. The results showed that the coercive field under a bipolar pulse at 3.0 MHz is 2.75 times as large as conventional defined Ec (2.58 kV/cm at 0.1 Hz), and a dc bias can further enlarge the driving field. Our results point to an innovative transducer operating mechanism at high frequencies since one could drive the crystal under much larger fields at high frequencies to produce much stronger signals from a small array element for deeper penetration imaging.
  • 9.

    【2hr】A tunable coupler for superconducting microwave resonators using a nonlinear kinetic inductance transmission line

    包量

    机译 使用非线性动电感传输线的用于超导微波谐振器的可调耦合器
    摘要：We present a tunable coupler scheme that allows us to tune the coupling strength between a feedline and a superconducting resonator in situ over a wide range. In this scheme, we shunt the feedline with a 50-Ω lumped-element nonlinear transmission line made from a 20 nm NbTiN film. By injecting a DC current, the nonlinear kinetic inductance changes and the effective impedance shunting the resonator periodically varies from a short to an open, which tunes the coupling strength and coupling quality factor Qc. We have demonstrated Qc tuning over a factor of 40, between Qc ~ 5.5 × 104 and Qc ~ 2.3 × 106, for a 4.5 GHz resonator by applying a DC current less than 3.3 mA. Our tunable coupler scheme is easy to implement and may find broad applications in superconducting detector and quantum computing/information experiments.
  • 10.

    【2hr】Reduced Photoconductivity Observed by Time-Resolved Terahertz Spectroscopy in Metal Nanofilms with and without Adhesion Layers

    包量

    机译 时间分辨太赫兹光谱法在具有和不具有粘附层的金属纳米膜中观察到的光电导率降低
    摘要：Non-contact, optical time-resolved terahertz spectroscopy (TRTS) has been used to study the transient photoconductivity of nanometer-scale metallic films deposited on fused quartz substrates. Samples of 8 nm thick gold or titanium show an instrument-limited (ca. 0.5 ps) decrease in conductivity following photoexcitation due to electron-phonon coupling and subsequent increased lattice temperatures which increases charge carrier scattering. In contrast, for samples of 8 nm gold with a 4 nm adhesion layer of titanium or chromium, a ca. 70 ps rise time for the lattice temperature increase is observed. These results establish the increased transient terahertz transmission sign change of metallic compared to semiconductor materials. The results also suggest nanoscale gold films that utilize an adhesion material do not consist of distinct layers.
  • 11.

    【2hr】A structure of CdS/CuxS quantum dots sensitized solar cells

    包量

    机译 CdS / CuxS量子点敏化太阳能电池的结构
    摘要：This work introduces a type of CdS/CuxS quantum dots (QDs) as sensitizers in quantum dot sensitized solar cells by in-situ cationic exchange reaction method where CdS photoanode is directly immersed in CuCl2 methanol solution to replace Cd2+ by Cu2+. The p-type CuxS layer on the surface of the CdS QDs can be considered as hole transport material, which not only enhances the light harvesting of photoanode but also boosts the charge separation after photo-excitation. Therefore, both the electron collection efficiency and power conversion efficiency of the solar cell are improved from 80% to 92% and from 1.21% to 2.78%, respectively.
  • 12.

    【2hr】High-extinction virtually imaged phased array-based Brillouin spectroscopy of turbid biological media

    包量

    机译 浊态生物介质的高消光虚拟成像相控阵布里渊光谱
    摘要：Brillouin microscopy has recently emerged as a powerful technique to characterize the mechanical properties of biological tissue, cell, and biomaterials. However, the potential of Brillouin microscopy is currently limited to transparent samples, because Brillouin spectrometers do not have sufficient spectral extinction to reject the predominant non-Brillouin scattered light of turbid media. To overcome this issue, we combined a multi-pass Fabry-Perot interferometer with a two-stage virtually imaged phased array spectrometer. The Fabry-Perot etalon acts as an ultra-narrow band-pass filter for Brillouin light with high spectral extinction and low loss. We report background-free Brillouin spectra from Intralipid solutions and up to 100 μm deep within chicken muscle tissue.
  • 13.

    【2hr】Strategies to improve phase-stability of ultrafast swept source optical coherence tomography for single shot imaging of transient mechanical waves at 16 kHz frame rate

    包量

    机译 改善超快扫频光源光学相干断层扫描的相位稳定性的策略，以16 kHz帧频对瞬态机械波进行单次成像
    摘要：We present single-shot phase-sensitive imaging of propagating mechanical waves within tissue, enabled by an ultrafast optical coherence tomography (OCT) system powered by a 1.628 MHz Fourier domain mode-locked (FDML) swept laser source. We propose a practical strategy for phase-sensitive measurement by comparing the phases between adjacent OCT B-scans, where the B-scan contains a number of A-scans equaling an integer number of FDML buffers. With this approach, we show that micro-strain fields can be mapped with ∼3.0 nm sensitivity at ∼16 000 fps. The system's capabilities are demonstrated on porcine cornea by imaging mechanical wave propagation launched by a pulsed UV laser beam, promising non-contact, real-time, and high-resolution optical coherence elastography.
  • 14.

    【2hr】Perforated hollow-core optical waveguides for on-chip atomic spectroscopy and gas sensing

    包量

    机译 带孔空心光波导，用于片上原子光谱和气体传感
    摘要：A hollow-core waveguide structure for on-chip atomic spectroscopy is presented. The devices are based on Anti-Resonant Reflecting Optical Waveguides and may be used for a wide variety of applications which rely on the interaction of light with gases and vapors. The designs presented here feature short delivery paths of the atomic vapor into the hollow waveguide. They also have excellent environmental stability by incorporating buried solid-core waveguides to deliver light to the hollow cores. Completed chips were packaged with an Rb source and the F = 3 ≥ F′ = 2, 3, 4 transitions of the D2 line in 85Rb were monitored for optical absorption. Maximum absorption peak depths of 9% were measured.
  • 15.

    【2hr】Direct growth of graphene on SiC(0001) by KrF-excimer-laser irradiation

    包量

    机译 KrF-准分子激光辐照在SiC（0001）上直接生长石墨烯
    摘要：In this report, we propose a direct patterning method of graphene on the SiC(0001) surface by KrF-excimer-laser irradiation. In this method, Si atoms are locally sublimated from the SiC surface in the laser-irradiated area, and direct graphene growth is induced by the rearrangement of surplus carbon on the SiC surface. Using Raman microscopy, we demonstrated the formation of graphene by laser irradiation and observed the growth process by transmission electron microscopy and conductive atomic force microscopy. When SiC was irradiated by 5000 shots of the laser beam with a fluence of 1.2 J/cm2, two layers of graphene were synthesized on the SiC(0001) surface. The number of graphene layers increased from 2 to 5–7 with an increase in the number of laser shots. Based on the results of conductive-atomic force microscopy measurements, we conclude that graphene formation was initiated from the step area, after which the graphene grew towards the terrace area by further Si evaporation and C recombination with increasing laser irradiation.
  • 16.

    【2hr】Experimental dynamic trapping of electrostatically actuated bistable micro-beams

    包量

    机译 静电驱动双稳态微束的实验动态陷获
    摘要：We demonstrate dynamic snap-through from a primary to a secondary statically inaccessible stable configuration in single crystal silicon, curved, doubly clamped micromechanical beam structures. Nanoscale motion of the fabricated bistable micromechanical devices was transduced using a high speed camera. Our experimental and theoretical results collectively show, that the transition between the two stable states was solely achieved by a tailored time dependent electrostatic actuation. Fast imaging of micromechanical motion allowed for direct visualization of dynamic trapping at the statically inaccessible state. These results further suggest that our direct dynamic actuation transcends prevalent limitations in controlling geometrically non-linear microstructures, and may have applications extending to multi-stable, topologically optimized micromechanical logic and non-volatile memory architectures.
  • 17.

    【2hr】Multifunctional-layered materials for creating membrane-restricted nanodomains and nanoscale imaging

    包量

    机译 用于创建膜受限纳米域和纳米级成像的多功能层材料
    • 作者：P. Srinivasan
    • 刊名：Applied Physics Letters
    • 2016年第3期
    摘要：Experimental platform that allows precise spatial positioning of biomolecules with an exquisite control at nanometer length scales is a valuable tool to study the molecular mechanisms of membrane bound signaling. Using micromachined thin film gold (Au) in layered architecture, it is possible to add both optical and biochemical functionalities in in vitro. Towards this goal, here, I show that docking of complementary DNA tethered giant phospholiposomes on Au surface can create membrane-restricted nanodomains. These nanodomains are critical features to dissect molecular choreography of membrane signaling complexes. The excited surface plasmon resonance modes of Au allow label-free imaging at diffraction-limited resolution of stably docked DNA tethered phospholiposomes, and lipid-detergent bicelle structures. Such multifunctional building block enables realizing rigorously controlled in vitro set-up to model membrane anchored biological signaling, besides serving as an optical tool for nanoscale imaging.
  • 18.

    【2hr】Quantitative contrast-enhanced optical coherence tomography

    包量

    机译 定量对比增强光学相干断层扫描
    摘要：We have developed a model to accurately quantify the signals produced by exogenous scattering agents used for contrast-enhanced Optical Coherence Tomography (OCT). This model predicts distinct concentration-dependent signal trends that arise from the underlying physics of OCT detection. Accordingly, we show that real scattering particles can be described as simplified ideal scatterers with modified scattering intensity and concentration. The relation between OCT signal and particle concentration is approximately linear at concentrations lower than 0.8 particle per imaging voxel. However, at higher concentrations, interference effects cause signal to increase with a square root dependence on the number of particles within a voxel. Finally, high particle concentrations cause enough light attenuation to saturate the detected signal. Predictions were validated by comparison with measured OCT signals from gold nanorods (GNRs) prepared in water at concentrations ranging over five orders of magnitude (50 fM to 5 nM). In addition, we validated that our model accurately predicts the signal responses of GNRs in highly heterogeneous scattering environments including whole blood and living animals. By enabling particle quantification, this work provides a valuable tool for current and future contrast-enhanced in vivo OCT studies. More generally, the model described herein may inform the interpretation of detected signals in modalities that rely on coherence-based detection or are susceptible to interference effects.
  • 19.

    【2hr】An electrically resistive sheet of glial cells for amplifying signals of neuronal extracellular recordings

    包量

    机译 胶质细胞的电阻片，用于放大神经元细胞外记录的信号
    摘要：Electrical signals of neuronal cells can be recorded non-invasively and with a high degree of temporal resolution using multielectrode arrays (MEAs). However, signals that are recorded with these devices are small, usually 0.01%–0.1% of intracellular recordings. Here, we show that the amplitude of neuronal signals recorded with MEA devices can be amplified by covering neuronal networks with an electrically resistive sheet. The resistive sheet used in this study is a monolayer of glial cells, supportive cells in the brain. The glial cells were grown on a collagen-gel film that is permeable to oxygen and other nutrients. The impedance of the glial sheet was measured by electrochemical impedance spectroscopy, and equivalent circuit simulations were performed to theoretically investigate the effect of covering the neurons with such a resistive sheet. Finally, the effect of the resistive glial sheet was confirmed experimentally, showing a 6-fold increase in neuronal signals. This technique feasibly amplifies signals of MEA recordings.
  • 20.

    【2hr】Low-noise kinetic inductance traveling-wave amplifier using three-wave mixing

    包量

    机译 采用三波混频的低噪声动电感行波放大器
    摘要：We have fabricated a wide-bandwidth, high dynamic range, low-noise cryogenic amplifier based on a superconducting kinetic inductance traveling-wave device. The device was made from NbTiN and consisted of a long, coplanar waveguide on a silicon chip. By adding a DC current and an RF pump tone we are able to generate parametric amplification using three-wave mixing. The devices exhibit gain of more than 15 dB across an instantaneous bandwidth from 4 to 8 GHz. The total usable gain bandwidth, including both sides of the signal-idler gain region, is more than 6 GHz. The noise referred to the input of the devices approaches the quantum limit, with less than 1 photon excess noise. Compared to similarly constructed four-wave mixing amplifiers, these devices operate with the RF pump at ~20 dB lower power and at frequencies far from the signal. This will permit easier integration into large scale qubit and detector applications.
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