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Pharmacokinetic metabolic stability plasma protein binding and CYP450s inhibition/induction assessment studies of N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide as potential type 5 phosphodiesterase inhibitors

机译：N-（2-吡啶基甲基）-2-羟甲基-1-吡咯烷基-4-（3-氯-4-甲氧基-苄基氨基）-5-嘧啶-的药代动力学代谢稳定性血浆蛋白结合和CYP450s抑制/诱导评估研究羧酰胺作为潜在的5型磷酸二酯酶抑制剂

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期刊名称 Animal Cells and Systems
作者
Haijun Qu; Xiaoxiao Hu; Xiaoli Shi; Chuan Wang; Longyuan Wang; Guoping Wang;
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作者单位

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年(卷),期 2019(23),3
年度 2019
页码 155–163
总页数 9
原文格式 PDF
正文语种
中图分类细胞生物学;动物学;
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入库时间 2022-08-17 16:19:50

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1. Pharmacokinetic, metabolic stability, plasma protein binding and CYP450s inhibition/induction assessment studies of N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide as potential type 5 phosphodiesterase inhibitors [J] . Haijun Qu, Xiaoxiao Hu, Xiaoli Shi, Animal Cells and Systems . 2019,第3期

机译：N-（2-吡啶基甲基）-2-氢氧甲基-1-吡咯烷基-4-（3-氯-4-甲氧基-苄氨基）-5-嘧啶-的药代动力学，代谢稳定性，血浆蛋白结合和CYP450s抑制/诱导评估研究羧酰胺作为潜在的5型磷酸二酯酶抑制剂
2. Assessment of in vitro metabolic stability, plasma protein binding, and pharmacokinetics of E- and Z-guggulsterone in rat [J] . Chhonker Yashpal S., Chandasana Hardik, Mukkavilli Rao, Drug testing and analysis . 2016,第9a10期

机译：评估大鼠中E-和Z-古古甾酮的体外代谢稳定性，血浆蛋白结合以及药代动力学
3. Plasma protein binding, pharmacokinetics, tissue distribution, excretion, enzyme kinetics and CYP450 biotransformation studies of novel antiplatelet agent S007-867 [J] . Chandasana Hardik, Chhonker Yashpal S., Laxman Tulsankar Sachin, Drug Metabolism Reviews . 2016,第1a4期

机译：新型抗血小板药物S007-867的血浆蛋白结合，药代动力学，组织分布，排泄，酶动力学和CYP450生物转化研究
4. Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential [O] . Zsuzsanna T. Varga, Alesha Grant, Balaji Manicassamy, 2012

机译：流感病毒蛋白PB1-F2通过与MAVS结合并降低线粒体膜电位来抑制I型干扰素的诱导。
5. Pharmacokinetic, metabolic stability, plasma protein binding and CYP450s inhibition/induction assessment studies of N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide as potential type 5 phosphodiesterase inhibitors [O] . Haijun Qu, Xiaoxiao Hu, Xiaoli Shi, 2019

机译：药代动力学，代谢稳定性，血浆蛋白结合和CYP450S抑制/诱导评估N-（2-吡啶甲基）-2-羟基甲基-1-吡咯烷基-4-（3-氯-4-甲氧基 - 苄基氨基）-5-嘧啶 - 羧酰胺作为潜在的5型磷酸二酯酶抑制剂

Pharmacokinetic metabolic stability plasma protein binding and CYP450s inhibition/induction assessment studies of N-(2-pyridylmethyl)-2-hydroxiymethyl-1-pyrrolidinyl-4-(3-chloro-4-methoxy-benzylamino)-5-pyrimidine-carboxamide as potential type 5 phosphodiesterase inhibitors

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