围生期心肌病患者血清B型脑钠肽与超敏C反应蛋白水平变化及临床意义

摘要

目的：探讨血清B型脑钠肽（BNP）与超敏C反应蛋白（hs- CRP）水平在围生期心肌病（PPCM）诊断及治疗中的价值。方法测定21例PPCM患者（观察组）BNP hs- CRP，同时行心脏彩色多普勒超声心动图检查测量左心室舒张末期内径（LVED）和左心室射血分数（LVEF），并对患者进行1个月的随访。选取同期住院的正常分娩患者20例作为对照组。结果观察组与对照组比较，BNP[（870.1±168.2）ng/L，（99.2±38.3）ng/L]、hs- CRP[（28.1±7.2）mg/L，（6.7±2.2）mg/L]明显升高（均P＜0.01），hs- CRP与BNP呈正相关（r＝0.67，P＜0.01）。经过1个月治疗，观察组平均LVEF由（33.1±9.5）％提高至（50.3±12.1）％，BNP、hs- CRP[治疗后分别为（196.6±40.2）ng/L、（7.8±3.1）mg/L)]明显下降（均P＜0.01）。结论 BNP及hs- CRP可以作为PPCM较好的诊断、治疗参考指标。%Objective To explore the clinical significances of the level changes of B type brain natriuretic peptide (BNP) and high sensitive C- reaction protein(hs- CRP) for diagnosis and treatment in peripartum cardiomyopathy(PPCM ). Methods A total of 21 PPCM and 20 normal delivery femals were randomly recruited in the current study.echocardiographic,hs- CRP,BNP were measured.21PPCM were fol owed up for a month. Results The PPCM patients compared to the controls, BNP(870.1ng/L) and hs- CRP (28.1mg/L) were significantly higher in the PPCM patients compared with the control (99.2ng/L and 6.7mg/L) hs- CRP was positively related with BNP(r=0.67,P<0.01).After a month of treatment,left ventricular ejection fraction enhanced from 33.1%to 50.3%, BNP significantly declined from 870.1ng/L to 196.6ng/L(P<0.01),hs- CRP significantly declined from 28.1mg/L to 7.8mg/L(P<0.01). Conclusion BNP and hs- CRP provide a good reference index for diagnosis and treatment in the PPCM.