目的：探讨多廿烷醇联合小剂量阿托伐他汀对老年（≥80岁）糖尿病合并高脂血症患者的降脂疗效及安全性。方法选择确诊糖尿病合并高脂血症的老年患者64例，分成两组，每组32例。联合治疗组采用多廿烷醇10mg联合阿托伐他汀10mg治疗，对照组单纯采用阿托伐他汀20mg治疗。治疗16周后比较两组治疗前后血脂、肝肾功能和肌酸激酶的变化。结果联合治疗组降低TC、LDL- C、TG优于对照组（P＜0.01）。联合治疗组总有效率为96.875%，阿托伐他汀组总有效率为71.875%，两组疗效的差异有统计学意义（P＜0.05）。两组不良反应发生率差异无统计学意义（P＞0.05），不良反应均较轻微，不需停药。结论多廿烷醇联合小剂量阿托伐他汀的降脂效果优于常规剂量阿托伐他汀，安全性和耐受性好，适用于老年糖尿病合并高脂血症患者。%Objective To evaluate the efficacy and safety of policosanol combined with low- dose atorvastatin for hyper-lipidemia in elderly patients with diabetes mel itus. Methods Sixty four patients aged≥80y with diabetes mellitus and hyperlipi-demia were assigned to receive policosanol 10mg and atorvastatin 10mg (combination group, n=32) or atorvastatin 20mg(control group, n=32). Blood lipids, liver function and creatine kinase changes were measure before and after treatment and compared between two groups. Results After 16 weeks of treatment, the reduction of total cholesterol(TC), low density lipoprotein choles-terol(LDL), triglycerides(TG) in combination group was more marked than that in control group(P<0.01). The total effective rate in combination and control groups was 96.875%and 71.875%, respectively(P<0.05). The adverse reactions in two group were mild and there was no significant difference in adverse effects between two groups (P> 0.05). Conclusion Policosanol combined with low dose atorvastatin is more effective in lowering blood lipids than conventional dose atorvastat for elderly diabetic patients with hyperlipidemia.
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