基于动脉自旋标记技术的正常大脑后循环血流分析

摘要

目的利用动脉自旋标记技术对正常大脑后循环进行MRI灌注成像，测量正常大脑后循环血流量，提供正常大脑后循环供血区血流量参考值。方法对60例志愿者进行MRI常规扫描和3D- ASL灌注扫描，获得血流量图，分别测得双侧枕叶、颞叶后部、小脑半球及脑干血流量（cerebral blood flow，CBF），结果进行统计分析。结果测得血流量，双侧枕叶为（64.45±12.72）ml/（min·100g）,颞叶后部为（63.28±14.97）ml/（min·100g），小脑半球为（61.75±13.54）ml/（min·100g），脑干为（53.64±12.71）ml/（min·100g），男性与女性的血流量未见差异；不同年龄段的血流量存在差异。结论3D- ASL能定量测量后循环血流量，对脑梗死的病理生理学的进一步研究有着重要价值。%Objective To apply 3D- arterial spin labeling (3D- ASL) MRI for analysis of normal posterior cerebral circula-tion. Methods 3D- ASL MRI scan was performed in 60 healthy subjects for analysis of posterior cerebral circulation. The param-eter maps of cerebral blood flow(CBF) was acquired,and the mean CBF was measured and analyzed. Results The mean CBFs of the occipital lobe, temporal lobe, cerebel ar hemisphere and brain stem were 64.45±12.72 ml/ (min·100g), 63.28±14.97ml/(min·100g), 61.75±13.54ml/ (min·100g) and 53.64±12.71 ml/ (min·100g), respectively. There was statistical difference in mean CBFs among different locations and ages, but no difference between males and females. Conclusion The results indicate that as a non- invasive technique ASL can provide useful perfusion information and would be used for pathophisiological study in pa-tients with cerebral infarction.