支气管镜刷检标本液基细胞学检测在肺癌诊断中的应用

摘要

Objective:To explore the clinical value of the SurePath liquid-based cytology test (LCT) in cytologi⁃cal screening of bronchial brushing for the diagnosis of lung cancer. Methods: Bronchial brushing specimens from 159 patients who were diagnosed as having lung cancer and 370 patients who were diagnosed as having be⁃nign lung disease were studied. The diagnostic sensitivity and cytological findings of LCT were compared with those of conventional smear (CS) method for diagnosing lung cancer. Results: LCT slides showed decreased areas of cell monolayers, a clearer background and distinct, stereoscopic cytological features. LCT had a significantly higher diagnostic sensitivity for lung cancer (43.4%) than the CS method (18.3%, P<0.05). The specificity was the same between the 2 methods. Of the 69 cases which had both LCT and histopathological results, LCT and pathology concordance rate was 76.8%. Conclusions: LCT in cytological screening of bronchial brushing has more diagnostic value of lung cancer and can be easily performed.%　　目的：探讨对支气管镜毛刷标本进行液基细胞学检测(LCT)在肺癌诊断中的应用价值.方法：收集159例肺癌患者和同期370例非肺癌患者的支气管镜刷检标本,同时进行LCT和直接涂片法检测,比较两种方法的涂片质量及诊断的阳性率.结果：LCT检测的标本切片质量高,LCT诊断肺癌的敏感度为43.4%,特异度为99.7%.直接涂片法诊断肺癌的敏感度为18.3%,特异度为99.7%.LCT的敏感度高于直接涂片法(P<0.01),特异度与直接涂片法无差异.159例肺癌患者中同时有LCT分类诊断和病理组织学诊断结果者69例,其中LCT分类诊断与病理组织学诊断相符53例,总符合率为76.8%.结论：LCT检测技术能提高肺癌诊断率,支气管镜刷检标本的LCT检测可推广应用于临床.