目的：比较还原型谷胱甘肽与硫普罗宁治疗药源性肝病的疗效。方法药源性肝病患者60例随机分为硫普罗宁治疗（27例）和还原型谷胱甘肽治疗（32例）两组。硫普罗宁组静脉滴硫普罗宁0.2g/次，1次/d，持续4周。还原型谷胱甘肽组静脉滴注还原型谷胱甘肽1.5g/次，1次/d，持续4周。比较两组患者症状、体征及肝功能指标、肝脾B超检查。结果两组患者治疗后的症状、肝功能指标和肝脾大小改善程度差异无统计学意义，总有效率差异也无统计学意义。结论还原型谷胱甘肽和硫普罗宁治疗药源性肝病疗效相当。%Objective To compare the effect of Reduced glutathione and tiopronin on the treatment of drug-induced liver disease. Methods From January 2012 to October 2012,60 cases of drug-induced liver disease patients treated in our hospital were enrolled in our study and randomly divided into 2 groups: 27 cases of tiopronin and 32 cases of reduced glutathione. Tiopronin group was administrated tiopronin 0.2g/d,for 4 weeks. Reduced glutathione group was administrated 1.5g/d,for 4 weeks. The symptoms and signs,liver function indicators and liver and spleen size detected by ultrasound were observed. Results Symptoms,liver function and the sizes of liver and spleen in 2 groups were improved after treatment,but had no significant differences(P>0.05). The total efficiency had no significant difference(P>0.05). Conclusion The effects of reduced glutathione and tiopronin in treatment of drug-induced liver disease are quite comparable.
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