目的观察雷贝拉唑与奥美拉唑治疗老年性消化性溃疡的临床疗效及安全性。方法将92例老年性消化性溃疡患者随机分为雷贝拉唑组（治疗组）46例，奥美拉唑组（对照组）46例。观察两组患者溃疡愈合率、幽门螺杆菌(Hp）根除率、不良反应等。结果雷贝拉唑组上腹疼痛消失率第1天为84.8%，第7天为95.7%，奥美拉唑组用药第1天为47.8%，第7天为76.1%，差异有统计学意义。观察组和对照组的溃疡愈合率分别为80.4%与52.2%，差异有统计学意义；观察组和对照组的总有效率分别为97.8%与82.6%，差异有统计学意义。治疗组和对照组的幽门螺杆菌根除率分别为84.8%与63.0%，差异有统计学意义。所有患者均未发现明显不良反应。结论雷贝拉唑和奥美拉唑治疗老年性消化性溃疡均有效安全，但雷贝拉唑在在缓解症状、促进溃疡愈合及根除幽门螺杆菌等方面均优于奥美拉唑。%Objective To compare the efficacy of rabeprazole and omeprazole in treatment of peptic ulcer in elderly people. Methods 92 patients suggestive of H pylori positive peptic ulcer by endoscope were enrolled. All patients were randomly divided into two groups:the observed group(n=46)and the control group(n=46).the eradication rate of pylori, the healing rate of peptic ulcer and adverse reactions were evaluated. Results The rates of ulcer pain disappearance in a day in observed group and the control group were 84.8%and 47.8%,the rates of ulcer pain disappearance in a week in the observed group and control group were 95.7%and 76.1%respectively,significant differences among 2 groups(P<0.01 and P<0.05). The ulcer healing rate in both group was 80.4% and 52.2%(P<0.05),the global effective rate in both group was 97.8%and 82.6%(P<0.01),and the H pylori eradication rate in both groups was 84.8% and 63.0%,respectively(P<0.01). Conclusion Rabeprazole is superior to omeprazole in improving symptoms and curing ulcers,and has better therapeutic effects for peptic ulcer in elderly.
展开▼
