As2O3和TACE对肝癌根治术后预防复发的疗效比较

摘要

Objective To evaluate the effect of As2O3 and TACE in the treatment of recurrence of hepatocellular carcinoma after radical resection. Methods A total of 48 patients with hepatocellular carcinoma,who underwent radical resection from April 2010 to February 2012,were randomly divided into two groups:As2O3 treatment group(study group)and TACE treatment group(control group),the drug side effects and liver cancer recurrence rate were compared. Results The 1-year recurrence rate of As2O3 group was lower than the TACE group,but not statistically significant;in As2O3 l group,the incidence ofⅠ/Ⅱfever/chills,nausea/vomiting and pain rate were significantly lower than the TACE group(P<0.05);both groups showed mild-moderate hepatic dysfunction,but not statistically significant. Conclusion The effect of As2O3 in the prevention of liver cancer recurrence after surgery is better than TACE,as it is an ideal method of treatment with well tolerated and no significant liver toxicity. It is worthy of clinical promotion.%目的：评估As2O3和TACE对肝癌根治术后预防复发的临床疗效比较。方法2010年4月至2012年2月收治48例肝癌根治性术后患者作为研究对象，随机分为两组，As2O3组（A组）24例和TACE组（B组）24例，随访1年，比较两组药物毒副作用、肝癌复发率。结果 As2O3组，1年复发率低于TACE组，但差异无统计学意义；As2O3实验组的Ⅰ/Ⅱ级，恶心/呕吐、发热/寒战、疼痛发生率均明显低于TACE对照组（P<0.05）；两组均出现轻-中度肝功能异常，但差异无统计学意义。结论在预防肝癌复发方面，三氧化二砷组略优肝动脉栓塞化疗组，患者不良反应小，耐受性好，值得临床推广。