2型糖尿病血糖与血清CA199水平的相关性分析

摘要

ObjectiveTo investigate the correlation between the change of serum CA199 level in the type 2 diabetes mellitus(T2DM). MethodsSelected 150 cases of T2DM patients in 2012 January ~2014 June in our hospital as test group,150 healthy people in the same period in our hospital out-patient examination as control group. The fasting blood glucose(FPG),fasting insulin(INS),glycosylated hemoglobin(HbAlc), triglyceride(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C)and CA199 of two groups were detected; study group was given conventional treatment of diabetes, FPG,INS,HbAlc and CA199 levels were observed before and after treatment. Results There were no difference in statistics of blood pressure,blood lipid levels in two groups(P>0.05),The test group FPG,HbAlc and CA199 were significantly higher than those in the control group(P<0.05),the test group INS,FC-P were significantly lower than those of the control group(P<0.05). After treatment the test group FPG,HbAlc and CA199 were significantly decreased,INS,FC-P increased significantly,there was significant difference compared with before treatment(P<0.05). Pearson correlation analysis showed a positive correlation with T2DM,CA199 levels in patients with FPG,HbAlc,negative correlation with INS and FC-P into(P<0.05).ConclusionT2DM patients have abnormal increase of serum CA199,and its mechanism may be related to glucose toxicity and acute inflammation.%目的：探讨2型糖尿病（T2DM）患者血清CA199水平变化及相关性。方法选择2012年1月至2014年6月T2DM患者150例为观察组，同期健康体检者150例为对照组。检测两组患者空腹血糖（FPG）、空腹胰岛素（INS）、糖化血红蛋白（HbAlc）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）及CA199；观察组予糖尿病常规治疗，观察治疗前后患者FPG、INS、HbAlc及CA199水平。结果两组患者血压、血脂水平比较差异无统计学意义（P>0.05），观察组FPG、HbAlc及CA199高于对照组（P<0.05），观察组INS低于对照组（P<0.05）。观察组治疗后FPG、HbAlc及CA199降低，INS升高，与治疗前比较差异有统计学意义（P<0.05）。Pearson相关性分析显示，T2DM患者CA199水平与FPG、HbAlc成正相关，与INS成负相关（均P<0.05）。结论 T2DM患者血清CA199异常升高，其机制可能与糖尿病患者糖毒性和急性炎症反应相关。