年轻STEMI患者动脉粥样硬化的形成与血小板平均体积的关系

摘要

Objective Increased mean platelet volume (MPV) is associated with poor clinical outcome in patients with acute coronary syndrome. We evaluated the predictive role of MPV in young patients with acute myocardial infarction (AMI). Methods This study includes 265 patients who were hospitalized in the First Affiliated Hospital of Soochow University with AMI (group 1 : 118 young patients,males aged<45 years and females aged<55 years;group 2:147 older patients) and 102 adults with normal coronary angiography as a control group (group3). Results In group 1,the proportion of smokers was higher than that in groups 2 an d 3(P1=0.01,P2<0.001);In group 1,the proportion of male patients was higher than that in group 3(P2<0.001);In group 1,the levels of Platelet count,MPV,Hemoglobin,Creatinine,Total cholesterol, LDL-C were higher than that in group 3(P2<0.05). Conclusion After multivariate analysis,MPV,age,Gender,Platelet count and Creatinine were independent predictors of AMI in young patients .%目的：评估血小板平均体积（MPV）在年轻急性心肌梗死（AMI）患者中的预测作用。方法 AMI患者265例，按年龄大小分为两组，A组118例（男<45岁，女<55岁）、B组147例（男>45岁，女>55岁）；另正常对照组102例（C组）。结果 A组患者吸烟比例明显高于B、C两组（P1=0.01，P2<0.001）；A组男性患者比例明显高于C组（P2<0.001）；A组患者血小板计数、MPV、血红蛋白、肌酐、总胆固醇、低密度脂蛋白胆固醇均高于C组（P2<0.05）。结论经多变量logistic回归分析发现，MPV、年龄、性别、血小板计数和肌酐是年轻AMI患者的独立预测因子。