肾移植术后1年环孢素血药浓度检测结果分析

摘要

Objective To detect the cyclosporine blood concentration on patients of one year postoperative of renal transplantation in our hospital,and analyze the result. Methods Cyclosporine blood concentration of 37 cases of patients in our hospital were given(renal transplant, RT)who were detected,the concentration of factors and influence of cyclosporine(postoperative time,gender,age)were given correlation analysis. Results After renal transplantation,with time passing,dosage,blood concentration decreased gradually,and individual difference was larger;There were no significant differences of blood concentration of cyclosporine between male group and female group(P>0.05);CsA dosage,blood concentration of group B(20-45 years old)higher than group A(>45 years old),the difference had statistical significance (P<0.05). Conclusion Patients after renal transplantation should be given the detection analysis regularly,therefore to reduce the toxicity after renal transplantation and the occurrence of adverse reactions.%目的：检测肾移植患者术后1年环孢素（CSA）血药浓度，并对结果进行分析。方法对37例肾移植（RT）患者的环孢素血药浓度进行检测，对环孢素血药浓度与影响因素（术后时间、性别、患者年龄）进行相关分析。结果肾移植患者术后随时间的延长，药剂量、血药浓度逐渐降低，且个体差异较大；男、女两组环孢素血药浓度差异无统计学意义（P>0.05）；B组（20~45岁）CsA用药剂量、血药浓度高于A（>45岁）组，差异有统计学意义（P<0.05）。结论肾移植患者术后定期进行规律的检测分析，对降低肾移植术后毒性和副反应发生具有重要意义。