Objective To analyze the relationship between migraine and the risk of cardiovascular disease. Methods Multiple electronic databases were detailedly searched to identify relevant studies. Data was analyzed using STATA 11. Results 14 non-randomized controlled studies (12 cohort studies,one cross-sectional study,one case-control study) were included. The pooled analysis indicated that there was significant relationship between myocardial infarction and angina pectoris and migraine compared to non-migraine,all P<0.05. However,we didn't find significant evidence with migraine and coronary artery revascularization,and ischemic heart disease mortality,all P>0.05. Conclusion This study indicates that migraine was a risk factor for myocardial infarction and angina,particularly migraine with aura.%目的 系统分析偏头痛与相关心血管疾病发生风险的关系.方法 检索中英文数据库,收集相关的研究,提取资料、评价文献质量,使用stata11.0软件进行Meta分析.结果 本研究纳入14篇非随机对照研究(12篇队列研究,1篇横截面研究,1篇病例对照研究),合并结果显示偏头痛心肌梗死及心绞痛发生风险具有相关性(P均<0.05),且女性中此相关性增加,而在不同偏头痛中,先兆偏头痛较无先兆偏头痛更能增加心肌梗死及心绞痛的发生风险.但偏头痛与冠脉重建、缺血性心脏病及其死亡率未见明显相关性(P均>0.05).结论 偏头痛与心肌梗死及心绞痛发生风险有相关性,且先兆偏头痛明显增高两者的风险.
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