强直性脊柱炎患者血清硬骨素水平与骨影像学变化的相关性分析

摘要

目的 探讨强直性脊柱炎(AS)患者血清硬骨素水平与脊柱影像学变化的关系.方法 选择门诊AS患者58例,同期门诊类风湿性关节炎(RA)患者25例及健康体检者25例作为对照组.采用酶联免疫吸附法检测各组血清硬骨素水平.评估AS患者血清硬骨素水平与各项临床指标、影像学进展之间的相关性.运用Pearson相关性分析法进行统计学分析.结果 AS组血清硬骨素浓度(65.9±21.7)pmol/L高于健康对照组(51.2±25.7)pmol/L,差异有显著性(P=0.0349);AS组血清硬骨素水平与患者年龄、病程、ASDAS评分、性别等均无关(P>0.05),但与mSASSS评分呈正相关(r=0.7).结论 AS患者血清硬骨素水平对疾病诊断有一定的意义,同时可作为AS影像学进展的生物学标志物之一,反应患者脊柱骨化程度.%Objective To study the relationship between serum levels of sclerostin and spine heterotopic ossification in patients with ankylosing spondylitis(AS). Methods 58 outpatient cases with AS,25 with rheumatoid arthritis(RA) and 25 healthy controls were collected. Enzyme-linked immunosorbent assay(ELISA)was applied to detect the serum levels of sclerostin in different groups. Further analysis to identify the correlation between serum levels of sclerostin and imaging progression of spine were evaluated in AS group. Pearson correlation analysis was performed for statistical analysis. Results Serum levels of sclerostin in AS patients(65.9±21.7)pmol/L were significantly higher than that of healthy controls [(51.2±25.7)pmol/L,P=0.0349]. There was positive correlation between serum sclerostin level and spine mSASSS score in AS patients (r=0.7),but without correlation with age,disease duration,AS disease activity scores and different genders(P>0.05). Conclusion Serum sclerostin level can be one of the useful indicators for diagnosis of AS,and may be a biological marker in imaging progression which can lead to evaluate the degree of spine ossification in AS.