Lewis酸离子液体催化合成2’，4’，6’-三甲基苯乙酮

摘要

Four kinds of Lewis acid ionic liquids were prepared, and their catalytic activities for Friedel- Crafts acylation of mesitylene and acetic anhydride were measured. The impacts of factors on the reaction were explored when [Emim]Br-AlCl3 was chosen as the catalyst and solvent. Under the conditions of 80 ℃, x（A1Cl3）-0.67 and n（[Emim]Br-AlCl3）： n（1,3,5-trimethylbenzene）：n（acetic anhydride）=1：3：1, the yield of the product could reach 73.4% after 6 h reaction.%合成了四种Lewis酸离子液体，考察其对均三甲苯和乙酸酐的Friedel—Crafts酰基化反应的催化活性后，选定以[Emim]Br—A1Cl3为溶剂兼催化剂合成2’，4’，6’一三甲基苯乙酮。探讨了A1C1，的摩尔分数、反应时间、反应温度和反应物摩尔比等因素对产物收率的影响。当inch摩尔分数x（AlCl3）=0．67，n（[Emim]Br—AICl3）：n（均三甲苯）：n（乙酸酐）=1：3：1，反应温度80℃，反应时间6h时，产物收率最高可达73．4％。