持久性有机污染物（POPs）生殖发育毒性的研究进展

摘要

持久性有机污染物（persistent organic pollutants,POPs）具有长期残留性、生物蓄积性、半挥发性及高毒性等特征，随着科学技术的发展，POPs的替代物质不断生产出，同时由于检测技术的发展，目前检测出某些POPs替代物质也拥有POPs类似的特性。它们对于人类的健康都存在很大的威胁。研究发现它们几乎对人类的各个系统存在危害。对于孕期暴露于POPs的子代也有毒性作用。本文主要综述了持久性有机污染物的生殖发育毒性及其相关机制的研究进展，希望为POPs的生殖发育毒性研究提供一些理论基础。%POPs （persistent organic pollutants, POPs） has long-term residual, bioaccumulation, semi-volatile and highly toxic characteristics, with the scientific and technological development, POPs alternative substances continue to produce, and because of detection technology development, POPs alternatives also have similar characteristics. They are a big threat for human health, study results suggest they are harmful to almost all systems of human, exposure to POPs for the offspring during pregnancy also have toxic effects. This paper reviews reproductive and developmental toxicity of persistent organic pollutants, and its related mechanism of progress, which can provide some theoretical basis for reproductive and developmental toxicity studies.