3,5-二溴-2-氨基吡嗪的合成

摘要

以廉价易得的2-氰基吡嗪作为起始原料，经水解、重排、水解一锅法得到2-氨基吡嗪，再用NBS溴化得到3,5-二溴-2-氨基吡嗪。本方法反应时间短，条件温和，具有较高的应用价值。%2-Amino pyrazine was prepared via hydrolysis, rearrangement and hydrolysis of one pot by using 2-cyanopyrazine, which is an inexpensive and easily available raw material. Then 3,5-dibromopyrazin-2-amine was got via NBS bromination. This method had short reaction time, mild conditions and higher application value.